Title:
METHODS OF USING TEMOZOLOMIDE IN THE TREATMENT OF CANCERS
Document Type and Number:
WIPO Patent Application WO2000033823
Kind Code:
A3
Abstract:
Methods are disclosed for treating cancer in a patient in need of such treating comprising administering temozolomide in an amount effective to achieve a clinical response wherein the temozolomide is administered in a microcrystalline suspension.
Inventors:
FRIEDMAN HENRY S
Application Number:
PCT/US1999/026033
Publication Date:
October 19, 2000
Filing Date:
December 02, 1999
Export Citation:
Assignee:
SCHERING CORP (US)
International Classes:
A61K9/14; A61K31/4188; (IPC1-7): A61K31/415; A61K9/14; A61P35/00
Domestic Patent References:
| WO1994015615A1 | 1994-07-21 |
Other References:
NEWLANDS E.S. ET AL: "Temozolomide: A review of its discovery, chemical properties, pre-clinical development and clinical trials.", CANCER TREATMENT REVIEWS, (1997) 23/1 (35-61)., XP000921344
ARCHER G E; SAMPSON J H; VILLAVICENCIO A T; MCLENDON R E; FRIEDMAN A H; BISHOP W R; BIGNER D D; FRIEDMAN H S: "Regional delivery of microcrystalline temozolomide for the treatment of neoplastic meningitis.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 40, 1999, pages 296, XP000914793
PLOWMAN, JACQUELINE ET AL: "Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea", CANCER RES. (1994), 54(14), 3793-9, XP000914803
DATABASE WPI Section Ch Week 199817, Derwent World Patents Index; Class B02, AN 1998-189166, XP002141134
BOBOLA, MICHAEL S. ET AL: "Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin", CLIN. CANCER RES. (1996), 2(4), 735-41, XP000914804
DONELLI M.G. ET AL: "Do anticancer agents reach the tumor target in the human brain?.", CANCER CHEMOTHERAPY AND PHARMACOLOGY, (1992) 30/4 (251-260)., XP000921354
ARCHER G E; SAMPSON J H; VILLAVICENCIO A T; MCLENDON R E; FRIEDMAN A H; BISHOP W R; BIGNER D D; FRIEDMAN H S: "Regional delivery of microcrystalline temozolomide for the treatment of neoplastic meningitis.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 40, 1999, pages 296, XP000914793
PLOWMAN, JACQUELINE ET AL: "Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea", CANCER RES. (1994), 54(14), 3793-9, XP000914803
DATABASE WPI Section Ch Week 199817, Derwent World Patents Index; Class B02, AN 1998-189166, XP002141134
BOBOLA, MICHAEL S. ET AL: "Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin", CLIN. CANCER RES. (1996), 2(4), 735-41, XP000914804
DONELLI M.G. ET AL: "Do anticancer agents reach the tumor target in the human brain?.", CANCER CHEMOTHERAPY AND PHARMACOLOGY, (1992) 30/4 (251-260)., XP000921354
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