Title:
METHODS OF UTILIZING CULTURED NON-GVHD INDUCING T LYMPHOCYTES TO TREAT DISEASE
Document Type and Number:
WIPO Patent Application WO2002043651
Kind Code:
A3
Abstract:
A method of treating a disease in a subject by administration of a non-GVHD inducing population of immune effector cells is disclosed. The method is effected by (a) co-culturing: (i) a first cell population comprising cells specifically immunoreactive to an antigen associated with the disease and cells not immunoreactive to the antigen associated with the disease; and (ii) a second cell population comprising cells being non-syngeneic with the subject and non-syngeneic with the first cell population, the second cell population and the culturing conditions being selected so as to induce proliferation of the cells specifically immunoreactive to an antigen associated with the disease; and (b) administering immune effector cells resultant from step (a) to the subject, thereby treating the disease without inducing GVHD.
Inventors:
REISNER YAIR (IL)
Application Number:
PCT/IL2001/001101
Publication Date:
August 01, 2002
Filing Date:
November 29, 2001
Export Citation:
Assignee:
YEDA RES & DEV (IL)
REISNER YAIR (IL)
REISNER YAIR (IL)
International Classes:
A61K39/00; A61P31/12; A61P35/00; C12N5/0783; C12P21/08; A61K35/12; (IPC1-7): A01N63/00
Foreign References:
| US6143292A | 2000-11-07 |
Other References:
See also references of EP 1337152A4
Download PDF: