METHYL 2-[(3S)-[3-[(2E)-(7-CHLORO QUINOLIN-2-YL) ETHENYL] PHENYL]-3-HALOPROPYL] BENZOATES

Title:

METHYL 2-[(3S)-[3-[(2E)-(7-CHLORO QUINOLIN-2-YL) ETHENYL] PHENYL]-3-HALOPROPYL] BENZOATES

Document Type and Number:

WIPO Patent Application WO2006008750

Kind Code:

A3

Abstract:

The present invention relates to the novel compounds Methyl 2-[(3S)-[3-[(2E) (7-chloro quinolin-2-yl) ethenyll phenyl]-3-halopropyl] benzoates (IV) wherein the halo is chloro, bromo, iodo, starting from the known compound Methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl) ethenyl] phenyl]-3-hydroxypropyl] benzoate (1). Reaction of Methyl 2-[(3S)-[3-[(2E) - (7-chloroquinolin-2-yl) ethenyl] phenyl]-3-hydroxypropyl] benzoate (1) with thionyl chloride or with methane sulfonyl chloride - lithium bromide or with trimethyl chlorosilane - sodium iodide in presence or absence of base gives Methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl) ethenyl] phenyl]-3-halopropyl] benzoates.

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Inventors:

CHAVA SATYANARAYANA (IN)
GORANTLA SEETA RAMANJANEYULU (IN)
INDUKURI VENKATA SUNIL KUMAR (IN)
SIMHADRI SRINIVAS (IN)

Application Number:

PCT/IN2004/000211

Publication Date:

December 21, 2006

Filing Date:

July 19, 2004

Export Citation:

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Assignee:

MATRIX LAB LTD (IN)
CHAVA SATYANARAYANA (IN)
GORANTLA SEETA RAMANJANEYULU (IN)
INDUKURI VENKATA SUNIL KUMAR (IN)
SIMHADRI SRINIVAS (IN)

International Classes:

C07D215/18

Foreign References:

US5565473A

1996-10-15

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