Title:
METHYLATION PATTERN ANALYSIS OF HAPLOTYPES IN TISSUES IN DNA MIXTURE
Document Type and Number:
WIPO Patent Application WO/2017/012544
Kind Code:
A1
Abstract:
Systems, apparatuses, and method are provided for determining the contributions of different tissues to a biological sample that includes a mixture of cell-free DNA molecules from various tissues types, e.g., as occurs in plasma or serum and other body fluids. Embodiments can analyze the methylation patterns of the DNA mixture (e.g., methylation levels at particular loci) for a particular haplotype and determine fractional contributions of various tissue types to the DNA mixture, e.g., of fetal tissue types or tissue types of specific organs that might have a tumor. Such fractional contributions determined for a haplotype can be used in a variety of ways.
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Inventors:
LO YUK-MING DENNIS (CN)
CHAN KWAN CHEE (CN)
CHIU ROSSA WAI KWUN (CN)
JIANG PEIYONG (CN)
SUN KUN (CN)
CHAN KWAN CHEE (CN)
CHIU ROSSA WAI KWUN (CN)
JIANG PEIYONG (CN)
SUN KUN (CN)
Application Number:
PCT/CN2016/090642
Publication Date:
January 26, 2017
Filing Date:
July 20, 2016
Export Citation:
Assignee:
UNIV HONG KONG CHINESE (CN)
International Classes:
C12Q1/68; G16B30/00
Domestic Patent References:
| WO2014043763A1 | 2014-03-27 | |||
| WO2011057094A1 | 2011-05-12 | |||
| WO2011057094A1 | 2011-05-12 |
Foreign References:
| US8467976B2 | 2013-06-18 | |||
| US20140080715A1 | 2014-03-20 |
Other References:
LO ET AL., SCI TRANSL MED, vol. 2, 2010, pages 61ra91
FAN ET AL., NAT BIOTECHNOL, vol. 29, 2011, pages 51 - 57
SNYDER ET AL., NAT REV GENET, vol. 16, 2015, pages 344 - 358
See also references of EP 3325663A4
FAN ET AL., NAT BIOTECHNOL, vol. 29, 2011, pages 51 - 57
SNYDER ET AL., NAT REV GENET, vol. 16, 2015, pages 344 - 358
See also references of EP 3325663A4
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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