Title:
METHYLTRANSFERASES AND THEIR USES
Document Type and Number:
WIPO Patent Application WO2006092631
Kind Code:
A3
Abstract:
The identification and cloning of Misu polypeptide are disclosed and in particular full length human and murine Misu polypeptides. The Misu polypeptides are shown to have methyltransferase activity for a range of nucleic acid substrates. The uses of these polypeptides and nucleic acid molecules are disclosed, for example for screening for compounds that are capable of modulating a Misu biological activity, and the use of Misu inhibitors for the treatment of cancer.
Inventors:
FRYE MICHAELA (GB)
WATT FIONA (GB)
WATT FIONA (GB)
Application Number:
PCT/GB2006/000796
Publication Date:
November 09, 2006
Filing Date:
March 03, 2006
Export Citation:
Assignee:
CANCER REC TECH LTD (GB)
FRYE MICHAELA (GB)
WATT FIONA (GB)
FRYE MICHAELA (GB)
WATT FIONA (GB)
International Classes:
C12N9/10; C07K16/18; C12N15/113; C12N15/54; C12Q1/68; G01N33/48; G01N33/50
Domestic Patent References:
| WO2004031364A2 | 2004-04-15 | |||
| WO2005038022A1 | 2005-04-28 |
Other References:
DATABASE EMBL [online] 9 March 2001 (2001-03-09), "Homo sapiens NOL1/NOP2/Sun domain family, member 2, mRNA (cDNA clone IMAGE:3505076), partial cds.", XP002397162, retrieved from EBI accession no. EM_PRO:BC001041 Database accession no. BC001041
FRYE M. ET AL: "Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment.", DEVELOPMENT (CAMBRIDGE), vol. 130, no. 12, June 2003 (2003-06-01), pages 2793 - 2808, XP002397160, ISSN: 0950-1991
LIU ZE-JUN ET AL: "Polymerase chain reaction-based methods of DNA methylation analysis", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 317, no. 2, 15 June 2003 (2003-06-15), pages 259 - 265, XP002318907, ISSN: 0003-2697
OAKELEY E J: "DNA METHYLATION ANALYSIS: A REVIEW OF CURRENT METHODOLOGIES", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 84, no. 3, 1999, pages 389 - 400, XP001029527, ISSN: 0163-7258
WIDSCHWENDTER M ET AL: "DNA METHYLATION AND BREAST CARCINOGENESIS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 21, no. 35, 12 August 2002 (2002-08-12), pages 5462 - 5482, XP009001821, ISSN: 0950-9232
BRANTL S: "Antisense-RNA regulation and RNA interference", BIOCHIMICA ET BIOPHYSICA ACTA . GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1575, no. 1-3, 3 May 2002 (2002-05-03), pages 15 - 25, XP004356720, ISSN: 0167-4781
FRYE MICHAELA ET AL: "The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.", CURRENT BIOLOGY : CB. 23 MAY 2006, vol. 16, no. 10, 23 May 2006 (2006-05-23), pages 971 - 981, XP005436711, ISSN: 0960-9822
See also references of EP 1863907A2
FRYE M. ET AL: "Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment.", DEVELOPMENT (CAMBRIDGE), vol. 130, no. 12, June 2003 (2003-06-01), pages 2793 - 2808, XP002397160, ISSN: 0950-1991
LIU ZE-JUN ET AL: "Polymerase chain reaction-based methods of DNA methylation analysis", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 317, no. 2, 15 June 2003 (2003-06-15), pages 259 - 265, XP002318907, ISSN: 0003-2697
OAKELEY E J: "DNA METHYLATION ANALYSIS: A REVIEW OF CURRENT METHODOLOGIES", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 84, no. 3, 1999, pages 389 - 400, XP001029527, ISSN: 0163-7258
WIDSCHWENDTER M ET AL: "DNA METHYLATION AND BREAST CARCINOGENESIS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 21, no. 35, 12 August 2002 (2002-08-12), pages 5462 - 5482, XP009001821, ISSN: 0950-9232
BRANTL S: "Antisense-RNA regulation and RNA interference", BIOCHIMICA ET BIOPHYSICA ACTA . GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1575, no. 1-3, 3 May 2002 (2002-05-03), pages 15 - 25, XP004356720, ISSN: 0167-4781
FRYE MICHAELA ET AL: "The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.", CURRENT BIOLOGY : CB. 23 MAY 2006, vol. 16, no. 10, 23 May 2006 (2006-05-23), pages 971 - 981, XP005436711, ISSN: 0960-9822
See also references of EP 1863907A2
Download PDF:
Previous Patent: EXTERIOR WATER TAP ASSEMBLY
Next Patent: DETECTING PARTIAL DISCHARGE IN HIGH VOLTAGE CABLES
Next Patent: DETECTING PARTIAL DISCHARGE IN HIGH VOLTAGE CABLES