MG7, SINGLE-CHAIN ANTIBODY SPECIFICALLY BINDING HIGHLY-GLYCOSYLATED CEA AND USE THEREOF IN DETECTION AND TREATMENT - CHINESE PEOPLE'S LIBERATION ARMY AIR FORCE MILITARY MEDICAL UNIV

Title:

MG7, SINGLE-CHAIN ANTIBODY SPECIFICALLY BINDING HIGHLY-GLYCOSYLATED CEA AND USE THEREOF IN DETECTION AND TREATMENT

Document Type and Number:

WIPO Patent Application WO/2018/019275

Kind Code:

A1

Abstract:

Disclosed are a glycosylated CEA-specific single-chain antibody, and a chimeric antigen receptor (CAR) targeting the glycosylated CEA, wherein same may be used for preparing reagents or drugs for diagnosing or treating tumours that overexpress glycosylated CEA.

Inventors:

FAN DAIMING (CN)
NIE YONGZHAN (CN)
WU KAICHUN (CN)
CAO YUEQIONG (CN)
YUAN JIJUN (CN)
YU XUEJUN (CN)

Application Number:

PCT/CN2017/094755

Publication Date:

February 01, 2018

Filing Date:

July 27, 2017

Export Citation:

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Assignee:

CHINESE PEOPLE'S LIBERATION ARMY AIR FORCE MILITARY MEDICAL UNIV (CN)
SHANGHAI GENECHEM CO LTD (CN)

International Classes:

C07K19/00; A61K35/17; A61P35/00; C07K16/30; C12N5/10; C12N15/62; G01N33/574

Domestic Patent References:

WO2015164594A1

2015-10-29

Foreign References:

CN104910279A	2015-09-16
CN104829733A	2015-08-12
CN104628859A	2015-05-20
CN1878562A	2006-12-13
CN102741293A	2012-10-17
CN105330750A	2016-02-17

Other References: