Title:
MICE HETEROZYGOUS FOR WFS1 GENE AS MOUSE MODELS FOR DEPRESSION
Document Type and Number:
WIPO Patent Application WO2001091548
Kind Code:
A3
Abstract:
The present invention describes a recombinant rodent model for depression. More particularly, the rodent comprises cells expressing mutations in the WFS1 gene. The rodent is preferably a mouse heterologous for mutations in exon 8 of the WFS1 gene. Preferably, the mutations yield a non-functional wolframin protein that lacks all or some of it transmembrane regions. Methods and compositions for making and using the mouse and cells thereof are disclosed.
Inventors:
ROBERDS STEVEN L (US)
HUFF RITA M (US)
HUFF RITA M (US)
Application Number:
PCT/US2001/017652
Publication Date:
July 24, 2003
Filing Date:
May 31, 2001
Export Citation:
Assignee:
UPJOHN CO (US)
ROBERDS STEVEN L (US)
HUFF RITA M (US)
ROBERDS STEVEN L (US)
HUFF RITA M (US)
International Classes:
C07K14/705; C12N15/85; (IPC1-7): A01K67/027; C07K14/705; G01N33/50
Domestic Patent References:
| WO2000018787A1 | 2000-04-06 |
Foreign References:
| DE19845277C1 | 2000-03-09 |
Other References:
SWIFT MICHAEL ET AL: "Psychiatric disorders and mutations at the Wolfram syndrome locus.", BIOLOGICAL PSYCHIATRY, vol. 47, no. 9, 1 May 2000 (2000-05-01), pages 787 - 793, XP002227813, ISSN: 0006-3223
STROM T M ET AL: "DIABETES INSIPIDUS, DIABETES MELLITUS, OPTIC ATROPHY AND DEAFNESS (DIDMOAD) CAUSED BY MUTATIONS IN A NOVEL GENE (WOLFRAMIN) CODING FOR A PREDICTED TRANSMEMBRANE PROTEIN", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 7, no. 13, December 1998 (1998-12-01), pages 2021 - 2028, XP002926970, ISSN: 0964-6906
See also references of EP 1353549A2
STROM T M ET AL: "DIABETES INSIPIDUS, DIABETES MELLITUS, OPTIC ATROPHY AND DEAFNESS (DIDMOAD) CAUSED BY MUTATIONS IN A NOVEL GENE (WOLFRAMIN) CODING FOR A PREDICTED TRANSMEMBRANE PROTEIN", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 7, no. 13, December 1998 (1998-12-01), pages 2021 - 2028, XP002926970, ISSN: 0964-6906
See also references of EP 1353549A2
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