Title:
MICELLAR COMPOSITIONS FOR USE IN BIOLOGICAL APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2011/039535
Kind Code:
A3
Abstract:
This invention relates to a composition comprising a micelle for use in biological applications, the micelle comprising: a substantially water-insoluble conjugated polymer which exhibits luminescence or fluorescence from about 300 nm to about 1500 nm of the electromagnetic spectrum: a biocompatible surfactant and/or lipid: and a MRI active agent.
Inventors:
GREEN MARK (GB)
HOWES PHILIP (GB)
HOWES PHILIP (GB)
Application Number:
PCT/GB2010/051620
Publication Date:
May 26, 2011
Filing Date:
September 28, 2010
Export Citation:
Assignee:
KING S COLLEGE LONDON (GB)
GREEN MARK (GB)
HOWES PHILIP (GB)
GREEN MARK (GB)
HOWES PHILIP (GB)
International Classes:
A61K49/00; A61K49/18; G01N33/58
Foreign References:
| US6022500A | 2000-02-08 | |||
| US20090036625A1 | 2009-02-05 |
Other References:
JANJIC JELENA M ET AL: "Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 5 MAR 2008 LNKD- PUBMED:18266363, vol. 130, no. 9, 5 March 2008 (2008-03-05), pages 2832 - 2841, XP002611878, ISSN: 1520-5126
NITIN N ET AL: "FUNCTIONALIZATION AND PEPTIDE-BASED DELIVERY OF MAGNETIC NANOPARTICLES AS AN INTRACELLULAR MRI CONTRAST AGENT", JBIC. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, SPRINGER, DE, vol. 9, no. 6, 30 June 2004 (2004-06-30), pages 706 - 712, XP008038832, ISSN: 0949-8257, DOI: DOI:10.1007/S00775-004-0560-1
BYEONG-SU KIM ET AL: "Magnetomicelles: composite nanostructures from magnetic nanoparticles and cross-linked amphiphilic block copolymers", NANO LETTERS AMERICAN CHEM. SOC USA, vol. 5, no. 10, October 2005 (2005-10-01), pages 1987 - 1991, XP002611879, ISSN: 1530-6984
GREEN M ET AL: "Simple conjugated polymer nanoparticles as biological labels", PROCEEDINGS OF THE ROYAL SOCIETY A: MATHEMATICAL, PHYSICAL AND ENGINEERING SCIENCES 20090908 ROYAL SOCIETY OF LONDON GBR, vol. 465, no. 2109, 8 September 2009 (2009-09-08), pages 2751 - 2759, XP002615546, DOI: DOI:10.1098/RSPA.2009.0181
HOWES PHILIP ET AL: "Synthesis, characterisation and intracellular imaging of PEG capped BEHP-PPV nanospheres.", CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND) 14 MAY 2009 LNKD- PUBMED:19532866, no. 18, 14 May 2009 (2009-05-14), pages 2490 - 2492, XP002615547, ISSN: 1359-7345
NITIN N ET AL: "FUNCTIONALIZATION AND PEPTIDE-BASED DELIVERY OF MAGNETIC NANOPARTICLES AS AN INTRACELLULAR MRI CONTRAST AGENT", JBIC. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, SPRINGER, DE, vol. 9, no. 6, 30 June 2004 (2004-06-30), pages 706 - 712, XP008038832, ISSN: 0949-8257, DOI: DOI:10.1007/S00775-004-0560-1
BYEONG-SU KIM ET AL: "Magnetomicelles: composite nanostructures from magnetic nanoparticles and cross-linked amphiphilic block copolymers", NANO LETTERS AMERICAN CHEM. SOC USA, vol. 5, no. 10, October 2005 (2005-10-01), pages 1987 - 1991, XP002611879, ISSN: 1530-6984
GREEN M ET AL: "Simple conjugated polymer nanoparticles as biological labels", PROCEEDINGS OF THE ROYAL SOCIETY A: MATHEMATICAL, PHYSICAL AND ENGINEERING SCIENCES 20090908 ROYAL SOCIETY OF LONDON GBR, vol. 465, no. 2109, 8 September 2009 (2009-09-08), pages 2751 - 2759, XP002615546, DOI: DOI:10.1098/RSPA.2009.0181
HOWES PHILIP ET AL: "Synthesis, characterisation and intracellular imaging of PEG capped BEHP-PPV nanospheres.", CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND) 14 MAY 2009 LNKD- PUBMED:19532866, no. 18, 14 May 2009 (2009-05-14), pages 2490 - 2492, XP002615547, ISSN: 1359-7345
Attorney, Agent or Firm:
WESTWOOD, Joanna (Goldings House2 Hays Lane, London SE1 2HW, GB)
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