Title:
MICRO-/NANOFLUIDIC ANALYZER AND METHOD FOR MANUFACTURING SAME
Document Type and Number:
WIPO Patent Application WO/2013/094316
Kind Code:
A1
Abstract:
Provided are a device structure for a micro/nanofluidic analyzer used to analyze DNA and a method for manufacturing the device structure, in which the vertical or horizontal movement of DNA within a channel can be controlled, and the measurement precision can be increased by improving the degree of control of the height of the channel. The invention is characterized in having: an electroconductive film provided on a substrate; a first electrode for applying a voltage to the electroconductive film; a groove part serving as a channel for a solution from the end face on one side of a first insulating film provided on the conductive film to the end face on the other side thereof, the upper face of the channel being open; at least one pair of electrode terminals provided opposing both side surfaces of the groove part; and second and third electrodes for applying a voltage to a wire connected to each of the pair of electrode terminals. When the solution is passed through the groove part, a voltage is applied between the second and third electrodes, and the electric signal flowing between the second and third electrodes via a sample contained in the solution is measured, whereby the sample is analyzed.
Inventors:
YANAGI ITARU (JP)
ISHIDA TAKESHI (JP)
YAMAMOTO JIRO (JP)
MINE TOSHIYUKI (JP)
AOKI MAYU (JP)
YANAGAWA YOSHIMITSU (JP)
ISHIDA TAKESHI (JP)
YAMAMOTO JIRO (JP)
MINE TOSHIYUKI (JP)
AOKI MAYU (JP)
YANAGAWA YOSHIMITSU (JP)
Application Number:
PCT/JP2012/078021
Publication Date:
June 27, 2013
Filing Date:
October 30, 2012
Export Citation:
Assignee:
HITACHI LTD (JP)
International Classes:
G01N27/00; C12Q1/68; G01N33/50; G01N35/08; G01N37/00
Domestic Patent References:
| WO2011067961A1 | 2011-06-09 |
Foreign References:
| JP2004233353A | 2004-08-19 | |||
| JP2006258813A | 2006-09-28 | |||
| JP2003510034A | 2003-03-18 | |||
| US6627067B1 | 2003-09-30 | |||
| JP2009025197A | 2009-02-05 |
Other References:
XIAOGAN LIANG ET AL.: "Nanogap Detector Inside Nanofluidic Channel for Fast Real-Time Label-Free DNA Analysis", NANO LETTERS, vol. 8, no. 5, 2008, pages 1472 - 1476
MASAKI TANIGUCHI: "Ichi Bunshi Kaiseki Gijutsu ni yoru Jijisedai DNA Sequencer no Kaihatsu", DAI 69 KAI HYOMEN KAGAKU KENKYUKAI YOSHISHU, 9 March 2011 (2011-03-09), pages 23 - 26
MAKUSU TSUTSUI ET AL.: "Transverse Field Effects on DNA-Sized Particle Dynamics", NANO LETTERS, vol. 9, no. 4, 2009, pages 1659 - 1662
MASAKI TANIGUCHI: "Ichi Bunshi Kaiseki Gijutsu ni yoru Jijisedai DNA Sequencer no Kaihatsu", DAI 69 KAI HYOMEN KAGAKU KENKYUKAI YOSHISHU, 9 March 2011 (2011-03-09), pages 23 - 26
MAKUSU TSUTSUI ET AL.: "Transverse Field Effects on DNA-Sized Particle Dynamics", NANO LETTERS, vol. 9, no. 4, 2009, pages 1659 - 1662
Attorney, Agent or Firm:
POLAIRE I. P. C. (JP)
Polaire Intellectual Property Corporation (JP)
Polaire Intellectual Property Corporation (JP)
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