Title:
MICRO-RNA ASSOCIATED WITH RHEUMATOID ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2010/001632
Kind Code:
A1
Abstract:
An object aims to provide a novel marker for rheumatoid arthritis (RA), more specifically a marker of which expression can be fluctuated in an RA-specific manner. Another object aims to confirm whether or not a specific type of miRNA (a marker) is involved in RA as a causal factor of RA and provide a detection method and a therapeutic agent for RA each of which utilizes the miRNA. A type of miRNA (e.g., miR124a) of which expression is fluctuated in a manner specific to an RA synovial cell is selected from a small RNA expression profile in an RA synovial cell, and the miRNA is used as a marker for RA. The therapeutic agent for RA comprises the miRNA (e.g., miR124a) as an active ingredient.
Inventors:
KAWANO, Seiji (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 01, 65785, JP)
河野 誠司 (〒01 兵庫県神戸市灘区六甲台町１番１号 国立大学法人神戸大学内 Hyogo, 65785, JP)
河野 誠司 (〒01 兵庫県神戸市灘区六甲台町１番１号 国立大学法人神戸大学内 Hyogo, 65785, JP)
Application Number:
JP2009/053157
Publication Date:
January 07, 2010
Filing Date:
February 23, 2009
Export Citation:
Assignee:
NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (1-1 Rokkodai-cho, Nada-ku Kobe-sh, Hyogo 01, 65785, JP)
国立大学法人神戸大学 (〒01 兵庫県神戸市灘区六甲台町１番１号 Hyogo, 65785, JP)
KAWANO, Seiji (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 01, 65785, JP)
国立大学法人神戸大学 (〒01 兵庫県神戸市灘区六甲台町１番１号 Hyogo, 65785, JP)
KAWANO, Seiji (1-1 Rokkodai-cho, Nada-ku, Kobe-sh, Hyogo 01, 65785, JP)
International Classes:
C12N15/09
Attorney, Agent or Firm:
SHOJI, Takashi et al. (6F Akiba Bldg, 3-4-1 Higashi-nihonbashi, Chuo-k, Tokyo 04, 10300, JP)