Title:
MICRO-RNA BIOMARKER FOR PREDICTING THERAPEUTIC EFFICACY OF OPIOID DRUG
Document Type and Number:
WIPO Patent Application WO/2018/159750
Kind Code:
A1
Abstract:
The present invention provides: a biomarker which contains specific micro-RNA occurring in plasma and is effective for the stratification of patients for which a pain therapy using an opioid drug is highly effective; and a method for using the biomarker. According to the present invention, it becomes possible to provide a method for analyzing the therapeutic efficacy of an opioid-containing drug for pains in a subject, said method comprising measuring the level of at least one miRNA selected from the group consisting of hsa-let-7f-5p, hsa-let-7a-5p, hsa-miR-423-3p, hsa-miR-26a-5p, hsa-miR-144-3p, hsa-miR-451a, hsa-miR-215, hsa-miR-363-3p and hsa-miR-16-5p.
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Inventors:
KIYOSAWA NAOKI (JP)
WATANABE KENJI (JP)
ISHIZUKA HITOSHI (JP)
WATANABE KENJI (JP)
ISHIZUKA HITOSHI (JP)
Application Number:
PCT/JP2018/007744
Publication Date:
September 07, 2018
Filing Date:
March 01, 2018
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12Q1/6883; A61K31/485; A61K45/00; A61P25/04; C12N15/09; C12Q1/6816; C12Q1/6851; C12Q1/686; G01N33/53; C12N15/113
Domestic Patent References:
| WO2015189345A2 | 2015-12-17 | |||
| WO2016127998A1 | 2016-08-18 |
Other References:
"Review on factor influencing amount of conversion during opioid rotation from oxycodone hydrochloride sustained-release tablet to transdermal fentanyl", THE ANNUAL MEETING OF JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCINECES, vol. 49, no. 10, 2013, pages 1103 - 1108
HAGEN, N. A. ET AL.: "Comparative clinical efficacy and safety of a novel controlled-release oxycodone formulation and controlled-release hydromorphone in the treatment of cancer pain", CANCER, vol. 79, no. 7, 1997, pages 1428 - 1437, XP055553584
HAGEN, N. A. ET AL.: "Comparative clinical efficacy and safety of a novel controlled-release oxycodone formulation and controlled-release hydromorphone in the treatment of cancer pain", CANCER, vol. 79, no. 7, 1997, pages 1428 - 1437, XP055553584
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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