Title:
MicroRNAS FOR THE GENERATION OF ASTROCYTES
Document Type and Number:
WIPO Patent Application WO/2013/124817
Kind Code:
A3
Abstract:
A method of generating a population of cells useful for treating a nerve disease or disorder in a subject, the method comprising up-regulating a level of at least one exogenous miRNA in mesenchymal stem cells (MSCs) and/or down-regulating a level of at least one miRNA using a polynucleotide agent that hybridizes to the miRNA, thereby generating the population of cells useful for treating the nerve disease or disorder. Isolated populations of cells with an astrocytic phenotype generated thereby and uses thereof are also provided.
Inventors:
BRODIE CHAYA (US)
SLAVIN SHIMON (IL)
SLAVIN SHIMON (IL)
Application Number:
PCT/IB2013/051430
Publication Date:
January 03, 2014
Filing Date:
February 21, 2013
Export Citation:
Assignee:
BRAINSTEM BIOTEC LTD (IL)
FORD HENRY HEALTH SYSTEM (US)
FORD HENRY HEALTH SYSTEM (US)
International Classes:
A61P25/00; C12N5/079; A61P25/16; C12N15/113
Domestic Patent References:
| WO2010144698A2 | 2010-12-16 | |||
| WO2012023132A1 | 2012-02-23 | |||
| WO2009144718A1 | 2009-12-03 | |||
| WO2006134602A2 | 2006-12-21 |
Other References:
KIM T-M ET AL: "A Developmental Taxonomy of Glioblastoma Defined and Maintained by MicroRNAs", CANCER RESEARCH, vol. 71, no. 9, May 2011 (2011-05-01), pages 3387 - 3399, XP055073956, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-10-4117
XIN H ET AL: "Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth", STEM CELLS, vol. 30, no. 7, 18 July 2012 (2012-07-18), pages 1556 - 1564, XP055073957, ISSN: 1066-5099, DOI: 10.1002/stem.1129
KANG J-G ET AL: "Kaposi's Sarcoma-Associated Herpesvirus ORF57 Promotes Escape of Viral and Human Interleukin-6 from MicroRNA-Mediated Suppression", JOURNAL OF VIROLOGY, vol. 85, no. 6, 15 March 2011 (2011-03-15), pages 2620 - 2630, XP055073965, ISSN: 0022-538X, DOI: 10.1128/JVI.02144-10
XIN H ET AL: "Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth", STEM CELLS, vol. 30, no. 7, 18 July 2012 (2012-07-18), pages 1556 - 1564, XP055073957, ISSN: 1066-5099, DOI: 10.1002/stem.1129
KANG J-G ET AL: "Kaposi's Sarcoma-Associated Herpesvirus ORF57 Promotes Escape of Viral and Human Interleukin-6 from MicroRNA-Mediated Suppression", JOURNAL OF VIROLOGY, vol. 85, no. 6, 15 March 2011 (2011-03-15), pages 2620 - 2630, XP055073965, ISSN: 0022-538X, DOI: 10.1128/JVI.02144-10
Attorney, Agent or Firm:
G.E. EHRLICH (1995) LTD. et al. (04 Ramat Gan, IL)
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