Title:
MICROAGGREGATES AND PRODUCTION METHOD FOR SAME
Document Type and Number:
WIPO Patent Application WO/2019/221015
Kind Code:
A1
Abstract:
[Problem] To provide: self-assembled microaggregates that are capable of encapsulating and supporting drugs, etc., using naturally derived plant materials to which the human body and environment are accustomed, and that are capable of being readily disassembled by chemical stimulation to release the drugs, etc; and a production method for the same. [Solution] Microaggregates in which the outermost component thereof forms a shell structure. The shell structure comprises a tannic acid derivative in which hydrogen atoms in at least some of the hydroxyl groups of tannic acid are substituted with linear hydrocarbon groups.
Inventors:
NAITO MASANOBU (JP)
PAYRA DEBABRATA (JP)
PAYRA DEBABRATA (JP)
Application Number:
PCT/JP2019/018672
Publication Date:
November 21, 2019
Filing Date:
May 10, 2019
Export Citation:
Assignee:
NAT INST MATERIALS SCIENCE (JP)
International Classes:
A61K47/26; A61K9/51; A61K31/337; A61K31/407; A61K31/43; A61K31/545; A61P3/00; A61P9/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; B01J13/04; A23L5/00
Domestic Patent References:
| WO2016076311A1 | 2016-05-19 | |||
| WO2017204359A1 | 2017-11-30 | |||
| WO2017074262A1 | 2017-05-04 |
Foreign References:
| JP2004307362A | 2004-11-04 |
Other References:
SHUTAVA, TATSIANA ET AL.: "pH responsive decomposable layer-by-layer nanofilms and capsules on the basis of tannic acid", MACROMOLECULES, vol. 38, 2 March 2005 (2005-03-02), pages 2850 - 2858, XP055658559
LIU, FEI ET AL.: "Encapsulation of anticancer drug by hydrogen-bonded multilayers of tannic acid", SOFT MATTER, vol. 10, no. 46, 14 December 2014 (2014-12-14), pages 9237 - 9247, XP055658560
SAMPLE, CAITLIN: "Hydrogen-bonded layer-by-layer assembly of poly(vinyl alcohol) and tannic acid, Bachelor Thesis", BACHELOR OF SCIENCE AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY, June 2014 (2014-06-01), pages 1 - 30, XP055577278
LIU, FEI ET AL.: "Encapsulation of anticancer drug by hydrogen-bonded multilayers of tannic acid", SOFT MATTER, vol. 10, no. 46, 14 December 2014 (2014-12-14), pages 9237 - 9247, XP055658560
SAMPLE, CAITLIN: "Hydrogen-bonded layer-by-layer assembly of poly(vinyl alcohol) and tannic acid, Bachelor Thesis", BACHELOR OF SCIENCE AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY, June 2014 (2014-06-01), pages 1 - 30, XP055577278
Attorney, Agent or Firm:
AIDA Satoru et al. (JP)
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