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Title:
MICROBIAL PRODUCTION OF TRITERPENOIDS INCLUDING MOGROSIDES
Document Type and Number:
WIPO Patent Application WO/2019/169027
Kind Code:
A3
Abstract:
The present invention provides host cells and methods for making mogrol glycosides, including Mogroside V (Mog. V), Mogroside VI (Mog. VI), Iso-Mogroside V (Isomog. V), and glycosylation products that are minor products in Siraitia grosvenorii. The invention provides engineered enzymes and engineered host cells for producing mogrol glycosylation products, such as Mog. V, Mog. VI, and Isomog. V, at high purity and/or yield. The present technology further provides methods of making products containing mogrol glycosides, such as Mog. V, Mog. VI, and Isomog. V, including food products, beverages, oral care products, sweeteners, and flavoring products.

Inventors:
PHILIPPE RYAN (US)
KUMARAN AJIKUMAR (US)
SANTOS CHRISTINE (US)
GOETTGE MICHELLE (US)
Application Number:
PCT/US2019/019886
Publication Date:
October 03, 2019
Filing Date:
February 27, 2019
Export Citation:
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Assignee:
MANUS BIO INC (US)
International Classes:
C12P33/00
Domestic Patent References:
WO2016029187A22016-02-25
Foreign References:
US20150322473A12015-11-12
US20170283844A12017-10-05
Other References:
GHIMIRE ET AL.: "Improved Squalene Production via Modulation of the Methylerythritol 4- Phosphate Pathway and Heterologous Expression of Genes from Streptomyces peucetius ATCC 27952 in Escherichia coli", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 75, no. 22, November 2009 (2009-11-01), pages 7291 - 7293, XP055640056
DATABASE UniProtKB [online] 6 February 2013 (2013-02-06), "Squalene synthase", XP055640061, Database accession no. K7NBW9_SIRGR
Attorney, Agent or Firm:
HAYMAN, Mark, L. et al. (US)
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