Title:
MICROBICIDE AND STERILIZATION METHOD
Document Type and Number:
WIPO Patent Application WO/2022/052047
Kind Code:
A1
Abstract:
Provided are a microbicide and a sterilization method, wherein the microbicide contains a compound represented by chemical formula (I), wherein Ar1 and Ar2 are each independently a substituent-substituted or unsubstituted phenyl, naphthyl, thienyl, furanyl, or pyridyl, and Ar1 and Ar2 are the same or different; the substituent is selected from a group consisting of a halogen, hydroxy, alkyl and alkoxy; and when Ar1 and Ar2 are each independently a phenyl substituted by two substituents, Ar1 and Ar2 are different.
Inventors:
HU ANREN (CN)
SHIH TZENGE-LIEN (CN)
HUNG SUNG-JEN (CN)
CHEN HAO-PING (CN)
SHIH TZENGE-LIEN (CN)
HUNG SUNG-JEN (CN)
CHEN HAO-PING (CN)
Application Number:
PCT/CN2020/114821
Publication Date:
March 17, 2022
Filing Date:
September 11, 2020
Export Citation:
Assignee:
TZU CHI UNIV (CN)
International Classes:
C07C49/255; A01P3/00; A61K31/05; A61K31/12; A61K31/34; A61K31/341; A61K31/381; A61K31/44; A61P31/04; C07C49/235; C07C49/248; C07D307/46; C07D333/22
Foreign References:
| CN108347927A | 2018-07-31 |
Other References:
HAUKVIK T, BRUZELL E, KRISTENSEN S, TØNNESEN H H: "A screening of curcumin derivatives for antibacterial phototoxic effects Studies on curcumin and curcuminoids. XLIII", PHARMAZIE, vol. 66, no. 1, 15 January 2011 (2011-01-15), DE , pages 69 - 74, XP055911205, ISSN: 0031-7144, DOI: 10.1691/ph.2011.0154
SOARES J. M. ET AL.: "Optimization for Microbial Incorporation and Efficiency of Photodynamic Therapy Using Variation on Curcumin Formulation", PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol. 29, 7 January 2020 (2020-01-07), XP086099340, ISSN: 1572-1000, DOI: 10.1016/j.pdpdt.2020.101652
POLAQUINI C. R. ET AL.: "Antibacterial Activity of 3, 3'-Dihydroxycurcumin (DHC) is Associated with Membrane Perturbation", BIOORGANIC CHEMISTRY, vol. 90, 7 June 2019 (2019-06-07), XP085760154, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2019.103031
LUO JIAOYANG, YANG MEIHUA: "Demethoxycurcumin: a potential antimicrobial agent : Exposure by microcalorimetry and modified broth microdilution method", JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, vol. 115, no. 3, 1 March 2014 (2014-03-01), NL , pages 2331 - 2338, XP055911215, ISSN: 1388-6150, DOI: 10.1007/s10973-013-3103-6
SINDHU, S.; THOMACHAN, SEENA; JOHN V. D.: "Synthesis, Characterization, and Biological Studies of 1,7-Diheteroaryl-1,6-Heptadiene-3,5-Dione and Their Metal Complexes", HETEROCYCLIC LETTERS, vol. 5, no. 2, 31 May 2015 (2015-05-31), India, pages 285 - 293, XP009535229, ISSN: 2230-9632
M. AKRAM KHAN; RIYAD EL-KHATIB; K.D. RAINSFORD; M.W. WHITEHOUSE;: "Synthesis and anti-inflammatory properties of some aromatic and heterocyclic aromatic curcuminoids", BIOORGANIC CHEMISTRY, vol. 40, US , pages 30 - 38, XP028443386, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2011.11.004
CHEN, LIMIN ET AL.: "Synthesis and in vitro Antioxidant Activity of Curcumin Analogs", NATURAL PRODUCT RESEARCH AND DEVELOPMENT, vol. 23, no. 4, 15 August 2011 (2011-08-15), pages 722 - 725, XP055911242, ISSN: 1001-6880
DING, TAO ET AL.: "Effect of Curcumin-mediated Photodynamic Therapy on Methicillin-resistant Staphylococcus Aureus and Biofilm in Vitro", CHINESE JOURNAL OF EXPERIMENTAL SURGERY, vol. 36, no. 6, 8 June 2019 (2019-06-08), pages 1 - 46, XP055911245, ISSN: 1001-9030
YANG MING-YEH; CHANG KAI-CHIH; CHEN LIANG-Yü; HU ANREN: "Low-dose blue light irradiation enhances the antimicrobial activities of curcumin againstPropionibacterium acnes", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, vol. 189, 26 September 2018 (2018-09-26), CH , pages 21 - 28, XP085552953, ISSN: 1011-1344, DOI: 10.1016/j.jphotobiol.2018.09.021
ZHENG DANTONG, HUANG CHONGXING, HUANG HAOHE, ZHAO YUAN, KHAN MUHAMMAD RAFI ULLAH, ZHAO HUI, HUANG LIJIE: "Antibacterial Mechanism of Curcumin: A Review", CHEMISTRY & BIODIVERSITY, HELVETICA CHIMICA ACTA, vol. 17, no. 8, 1 August 2020 (2020-08-01), CH , XP055911251, ISSN: 1612-1872, DOI: 10.1002/cbdv.202000171
SOARES J. M. ET AL.: "Optimization for Microbial Incorporation and Efficiency of Photodynamic Therapy Using Variation on Curcumin Formulation", PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, vol. 29, 7 January 2020 (2020-01-07), XP086099340, ISSN: 1572-1000, DOI: 10.1016/j.pdpdt.2020.101652
POLAQUINI C. R. ET AL.: "Antibacterial Activity of 3, 3'-Dihydroxycurcumin (DHC) is Associated with Membrane Perturbation", BIOORGANIC CHEMISTRY, vol. 90, 7 June 2019 (2019-06-07), XP085760154, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2019.103031
LUO JIAOYANG, YANG MEIHUA: "Demethoxycurcumin: a potential antimicrobial agent : Exposure by microcalorimetry and modified broth microdilution method", JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, vol. 115, no. 3, 1 March 2014 (2014-03-01), NL , pages 2331 - 2338, XP055911215, ISSN: 1388-6150, DOI: 10.1007/s10973-013-3103-6
SINDHU, S.; THOMACHAN, SEENA; JOHN V. D.: "Synthesis, Characterization, and Biological Studies of 1,7-Diheteroaryl-1,6-Heptadiene-3,5-Dione and Their Metal Complexes", HETEROCYCLIC LETTERS, vol. 5, no. 2, 31 May 2015 (2015-05-31), India, pages 285 - 293, XP009535229, ISSN: 2230-9632
M. AKRAM KHAN; RIYAD EL-KHATIB; K.D. RAINSFORD; M.W. WHITEHOUSE;: "Synthesis and anti-inflammatory properties of some aromatic and heterocyclic aromatic curcuminoids", BIOORGANIC CHEMISTRY, vol. 40, US , pages 30 - 38, XP028443386, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2011.11.004
CHEN, LIMIN ET AL.: "Synthesis and in vitro Antioxidant Activity of Curcumin Analogs", NATURAL PRODUCT RESEARCH AND DEVELOPMENT, vol. 23, no. 4, 15 August 2011 (2011-08-15), pages 722 - 725, XP055911242, ISSN: 1001-6880
DING, TAO ET AL.: "Effect of Curcumin-mediated Photodynamic Therapy on Methicillin-resistant Staphylococcus Aureus and Biofilm in Vitro", CHINESE JOURNAL OF EXPERIMENTAL SURGERY, vol. 36, no. 6, 8 June 2019 (2019-06-08), pages 1 - 46, XP055911245, ISSN: 1001-9030
YANG MING-YEH; CHANG KAI-CHIH; CHEN LIANG-Yü; HU ANREN: "Low-dose blue light irradiation enhances the antimicrobial activities of curcumin againstPropionibacterium acnes", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B: BIOLOGY, vol. 189, 26 September 2018 (2018-09-26), CH , pages 21 - 28, XP085552953, ISSN: 1011-1344, DOI: 10.1016/j.jphotobiol.2018.09.021
ZHENG DANTONG, HUANG CHONGXING, HUANG HAOHE, ZHAO YUAN, KHAN MUHAMMAD RAFI ULLAH, ZHAO HUI, HUANG LIJIE: "Antibacterial Mechanism of Curcumin: A Review", CHEMISTRY & BIODIVERSITY, HELVETICA CHIMICA ACTA, vol. 17, no. 8, 1 August 2020 (2020-08-01), CH , XP055911251, ISSN: 1612-1872, DOI: 10.1002/cbdv.202000171
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
Download PDF: