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Title:
MICROBIOLOGICAL METHOD FOR THE PRODUCTION OF 7 ALPHA-SUBSTITUTED 11 ALPHA-HYDROXYSTEROIDS
Document Type and Number:
WIPO Patent Application WO2004011663
Kind Code:
A3
Abstract:
Disclosed is a new synthetic pathway for the production of precursors for the production of compounds having general formula (8,10,12). During said synthesis, compounds of general formal (4,B) are produced in a microbiological reaction. The meanings of radicals R<7>, R<10>, R<11>, R<13>, R<17> and R<17'> and group U-V-W-X-Y-Z are defined in the patent claims.

Inventors:
ZORN LUDWIG (DE)
BOHLMANN ROLF (DE)
GALLUS NORBERT (DE)
KUENZER HERMANN (DE)
MUHN HANS-PETER (DE)
NUBBEMEYER REINHARD (DE)
Application Number:
EP0308111W
Publication Date:
July 15, 2004
Filing Date:
July 24, 2003
Export Citation:
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Assignee:
SCHERING AKTIENGESELLSCHAFT
ZORN, LUDWIG
BOHLMANN, ROLF
GALLUS, NORBERT
KUENZER, HERMANN
MUHN, HANS-PETER
NUBBEMEYER, REINHARD
International Classes:
C07J1/00; C07J3/00; C07J5/00; C07J7/00; C07J9/00; C07J11/00; C07J31/00; C07J41/00; C12P33/10; C12P33/16; (IPC1-7): C12P33/10; C12P33/16; C07J1/00; C07J3/00; C07J5/00; C07J7/00; C07J9/00; C07J11/00; C07J31/00; C07J41/00; A61K31/56
Domestic Patent References:
WO1997021830A11997-06-19
WO2002059139A12002-08-01
WO1999013812A11999-03-25
WO2004011008A12004-02-05
Other References:
TAN L ET AL: "INTERACTIONS OF STEROIDS AND FUNGI. 11 ALPHA-HYDROXYLATION AND DEGRADATION OF PROGESTERONE-4-C BY A CELL-FREE PREPARATION FROM ASPERGILLUS OCHRACEUS", JOURNAL OF STEROID BIOCHEMISTRY, PERGAMON PRESS PLC, GB, vol. 1, no. 3, 1 September 1970 (1970-09-01), pages 221 - 227, XP000671122, ISSN: 0022-4731
SHIBAHARA M ET AL: "MICROBIAL HYDROXYLATIONS V. IIALPHA-HYDROXYLATION OF PROGESTERONE BY CELL-FREE PREPARATIONS OF ASPERGILLUS OCHRACEUS", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 202, 1970, pages 172 - 179, XP009023368, ISSN: 0006-3002
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