Title:
MICROCHIP AND DEVICE FOR QUANTITATIVE ANALYSIS OF ANTIGEN, AND METHOD FOR QUANTITATIVE ANALYSIS OF ANTIGEN USING SAME
Document Type and Number:
WIPO Patent Application WO/2019/093542
Kind Code:
A1
Abstract:
The present invention provides a method for quantitative analysis of an antigen, the method comprising the steps of: mixing a target antigen-containing sample to be analyzed, magnetic particles onto which a first antibody conducting an antigen-antibody reaction with the target antigen is immobilized, and beads onto which a second antibody different from the first antibody is immobilized; loading the mixed sample to be analyzed onto a microchip for quantitative analysis of an antigen; introducing the microchip for quantitative analysis of an antigen into a digital indicating microscopy-based detector comprising a magnetic power receiving portion, followed by applying magnetic power to the magnetic power receiving portion; and detecting the beads by means of the image acquired by the detector to count the number of the target antigens.
Inventors:
CHOI JUN KYU (KR)
Application Number:
PCT/KR2017/012678
Publication Date:
May 16, 2019
Filing Date:
November 09, 2017
Export Citation:
Assignee:
SMALL MACHINES (KR)
International Classes:
G01N15/14; G01N33/53
Foreign References:
| KR20060094416A | 2006-08-29 | |||
| US20040009614A1 | 2004-01-15 | |||
| KR20120062257A | 2012-06-14 |
Other References:
CUMHUR, TEKIN, H. ET AL.: "Ultrasensitive Protein Detection: a Case for Microfluidic Magnetic Bead-based Assays", LAB ON A CHIP, vol. 13, no. 24, 2013, pages 4711 - 4739, XP055599205
VAN DORST, BIEKE ET AL.: "Integration of an Optical CMOS Sensor with a Microfluidic Channel Allows a Sensitive Readout for Biological Assay s in Point-of-care Tests", BIOSENSORS AND BIOELECTRONICS, vol. 78, 2016, pages 126 - 131, XP055607689
VAN DORST, BIEKE ET AL.: "Integration of an Optical CMOS Sensor with a Microfluidic Channel Allows a Sensitive Readout for Biological Assay s in Point-of-care Tests", BIOSENSORS AND BIOELECTRONICS, vol. 78, 2016, pages 126 - 131, XP055607689
Attorney, Agent or Firm:
INVENTUS INTELLECTUAL PROPERTY GROUP (KR)
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