Title:
MICROENABLED CHEMICAL REACTION IN MICROFLUIDIC CHIPS
Document Type and Number:
WIPO Patent Application WO2000076662
Kind Code:
A3
Abstract:
A chemical process to obtain products of higher purity or in shorter time is provided by performing chemical reactions in a reactions volume less than 1 microliter. The advantages of this process are due to better mixing or heat exchanche (each 10 fold decrease in reaction volume leads to a 100-fold improvement mixing or heat exchange) or better surface to volume ratio. Better surface to volume ratio is a major factor in reactions critically dependent on surface mediated events such as heterogeneous catalysis. This increase in yield and speed of reaction can be conducted in parallel sets of reaction chambers provided by multilayer glass and silicon chips. Reagents can be added via a microfluidic chip incorporating channels and orthogonal row/column reagent delivery options. This discovery is amendable to solid supported synthesis as well as solution synthesis. Because of the better surface to volume ratio, this process is particularly useful with solid catalyst on the edges of the reaction chamber and can be used for hydrogenation, and hydroformulation. This process is demonstrated in reactions involving nucleophilic aromatic substitution on a solid support.
Inventors:
SWENSON ROLF E
JIAN LIN
DEWITT SHEILA H
JIAN LIN
DEWITT SHEILA H
Application Number:
PCT/US2000/016056
Publication Date:
June 28, 2001
Filing Date:
June 12, 2000
Export Citation:
Assignee:
ORCHID BIOSCIENCES INC (US)
International Classes:
B01J19/00; B01L3/00; C07B61/00; C07C45/50; C07C205/58; C07C227/08; C07K1/04; C07C229/60; C40B40/10; C40B50/14; C40B60/14; (IPC1-7): C12Q1/00; A61K38/00; C07H21/00; C07H21/02; C07H21/04; C12Q1/68
Foreign References:
| US5472672A | 1995-12-05 | |||
| US5474796A | 1995-12-12 | |||
| US5585275A | 1996-12-17 | |||
| US5008040A | 1991-04-16 | |||
| US5741862A | 1998-04-21 | |||
| US6001311A | 1999-12-14 | |||
| US5605662A | 1997-02-25 |
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