Title:
MICROENCAPSULATION OF DRUGS BY SOLVENT EXCHANGE
Document Type and Number:
WIPO Patent Application WO2003053325
Kind Code:
A3
Abstract:
A solvent exchange method is employed to provide microencapsulated compositions, such as microcapsules of pharmaceutical preparations. The method is based on an exchange of water and a hydrophilic organic solvent, whereby a decline in solvent quality for the organic solvent causes a polymer dissolved therein to be deposited onto an aqueous core. Optimal results are rationalized in terms of a balance of water solubility and surface tension for the organic solvent. In a preferred embodiment, microcapsules of selected drugs are formed by contacting microdroplets of an aqueous solution containing the drug with the organic solvent containing a polymer dissolved therein. A preferred method employs biodegradable poly(lactic acid-co-glycolic acid) (PLGA) dissolved in acetic acid, ethyl acetate, methyl acetate, or ethyl formate, to form a PLGA membrane around an aqueous drug core. The method is particularly attractive for encapulsating protein-based drugs without substantial denaturation.
Inventors:
YEO YOON
CHEN ALVIN UN-TEH
BASARAN OSMAN A
PARK KINAM
CHEN ALVIN UN-TEH
BASARAN OSMAN A
PARK KINAM
Application Number:
PCT/US2001/048420
Publication Date:
October 23, 2003
Filing Date:
December 13, 2001
Export Citation:
Assignee:
PURDUE RESEARCH FOUNDATION (US)
International Classes:
A61K9/52; A61K9/50; A61K31/7088; A61K31/711; A61K38/00; A61K47/34; A61P5/00; A61P43/00; B01J13/04; (IPC1-7): B32B15/00
Foreign References:
| US5747390A | 1998-05-05 | |||
| US6296667B1 | 2001-10-02 | |||
| US6306424B1 | 2001-10-23 |
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