Title:
MICROFLUID DEVICE WITH SAMPLE INJECTOR AND METHOD OF USE
Document Type and Number:
WIPO Patent Application WO2001059440
Kind Code:
A3
Abstract:
A method and device for injecting a liquid sample into an electrolyte channel in a microfluidics device is disclosed. The device has a channel network that includes an electrolyte channel having upstream and downstream channel portions and first, second, and third side channels that intersect the electrolyte channel between the two channel portions at first, second, and third ports, respectively. In the method, a sample is moved electrokinetically into the electrolyte channel, to form a defined sample volume therein. By simultaneously controlling the voltage applied to the three side channels, and at least one of the upstream and downstream channel end portions, the sample volume element can be shaped to have a desired leading- and trailing-edge shape and/or distribution of sample components within the volume elements.
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Inventors:
WILLIAMS STEPHEN J
TAN HONG DONG
KAO HUNG PIN
VREELAND WYATT N
TAN HONG DONG
KAO HUNG PIN
VREELAND WYATT N
Application Number:
PCT/US2001/004412
Publication Date:
June 27, 2002
Filing Date:
February 10, 2001
Export Citation:
Assignee:
ACLARA BIOSCIENCES INC (US)
International Classes:
B01D57/02; B01J19/00; B01L3/00; B03C5/00; C07K1/28; C08F2/58; G01N27/447; G01N37/00; B81B1/00; (IPC1-7): G01N27/447
Domestic Patent References:
| WO1998049548A1 | 1998-11-05 |
Foreign References:
| US5869004A | 1999-02-09 | |||
| US5599432A | 1997-02-04 | |||
| US5858195A | 1999-01-12 | |||
| US5858187A | 1999-01-12 |
Other References:
PIER GIORGIO RIGHETTI (ED): "Capillary electrophoresis in analytical biotechnology", 1996, CRC PRESS, NEW YORK, XP008002033
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