Title:
MICROFLUIDIC CHIP AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/019526
Kind Code:
A1
Abstract:
Disclosed are a microfluidic chip and an application thereof. The chip is a multi-layer structure, wherein the multi-layer structure thereof specifically involves: an upper-layer substrate (1c), an upper-layer elastic porous membrane (2b), an intermediate-layer substrate (1b), a lower-layer elastic porous membrane (2a) and a lower-layer substrate (1a) being comprised in sequence from top to bottom, wherein a flexible lumen structure is formed by an upper-layer channel (3), a lower-layer channel (3b) and an intermediate-layer channel (3a) with the upper-layer elastic porous membrane (2b) and the lower-layer elastic porous membrane (2a), respectively. When the fluid pressure in the upper- and lower-layer channels is inconsistent with the fluid pressure in the intermediate-layer channel, the upper- and lower-layer elastic porous membranes deform due to the pressure difference, such that the microfluidic chip can simulate a flexible lumen or organ and tissue with a lumen structure in the human body to a high simulation degree, and thus, a biomarker can be tested to realize the effective evaluation of a drug, cosmetics, a health care product and an environmental toxin.
Inventors:
LUO YONG (CN)
DU YUGUANG (CN)
SUN MING (CN)
DENG QUANFENG (CN)
DU YUGUANG (CN)
SUN MING (CN)
DENG QUANFENG (CN)
Application Number:
PCT/CN2017/115760
Publication Date:
January 31, 2019
Filing Date:
December 12, 2017
Export Citation:
Assignee:
ZHONGKE XINRAY SUZHOU BIOLOGICAL TECH CO LTD (CN)
International Classes:
C12M3/06; C12M1/00; C12M1/12
Domestic Patent References:
| WO2007058433A8 | 2007-10-11 |
Foreign References:
| CN107312713A | 2017-11-03 | |||
| CN104830683A | 2015-08-12 | |||
| CN106807456A | 2017-06-09 | |||
| CN204625653U | 2015-09-09 | |||
| CN106811413A | 2017-06-09 | |||
| CN101510518A | 2009-08-19 |
Attorney, Agent or Firm:
SHANGHAI SHUONEE INTELLECTUAL PROPERTY LAW OFFICE (CN)
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