Title:
MICROFLUIDIC DEVICE CAPABLE OF CONFIRMING SUSTAINED ANTICANCER ACTIVITY OF DRUG AND EPR EFFECT OF NANOPARTICLE FORMULATION OF DRUG
Document Type and Number:
WIPO Patent Application WO/2024/034888
Kind Code:
A1
Abstract:
The present invention relates to a microfluidic device capable of confirming sustained anticancer activity of a drug and the enhanced permeability and retention (EPR) effect of a nanoparticle formulation of the drug, and a method for confirming sustained anticancer activity of a drug and the EPR effect of a nanoparticle formulation of the drug using same. As the microfluidic device according to the present invention has a structure in which an upper cap having a fluid inlet, a fluid outlet, and a fluid passage, and a lower body having a chamber capable of accommodating a tumoroid, are separated, the microfluidic device may easily, quickly, and conveniently accommodate, directly in the chamber, tumoroids of a large size (600 μm or more) suitable for research on anticancer drug-based nanoinjection formulations. In addition, the microfluidic device according to the present invention enables continuous cytotoxicity analysis of an anticancer drug by means of a membrane filter made of a hydrophilic material with a specific pore size (100 to 300 nm) formed between the upper cap and the lower body and, at the same time, has the advantage of being capable of confirming the EPR effect of a nanoparticle formulation of the drug.
Inventors:
SHIN DAE HWAN (KR)
YOON MOON SUP (KR)
LEE JAE MIN (KR)
YOON MOON SUP (KR)
LEE JAE MIN (KR)
Application Number:
PCT/KR2023/010066
Publication Date:
February 15, 2024
Filing Date:
July 14, 2023
Export Citation:
Assignee:
NAT UNIV CHUNGBUK IND ACAD COOP FOUND (KR)
International Classes:
C12M1/34; C12M1/00; C12M3/00; C12M3/06; G01N33/50
Foreign References:
| JP6140684B2 | 2017-05-31 | |||
| KR20180052546A | 2018-05-18 | |||
| KR102400288B1 | 2022-05-23 | |||
| KR20220027661A | 2022-03-08 |
Other References:
WANG HAO-FEI, RAN RUI, LIU YUN, HUI YUE, ZENG BIJUN, CHEN DONG, WEITZ DAVID A., ZHAO CHUN-XIA: "Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 11, 27 November 2018 (2018-11-27), US , pages 11600 - 11609, XP093139424, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b06846
TIAN CHUTONG, ZHENG SHUNZHE, LIU XINYING, KAMEI KEN-ICHIRO: "Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system", JOURNAL OF NANOBIOTECHNOLOGY, BIOMED CENTRAL, vol. 20, no. 1, 1 December 2022 (2022-12-01), XP093139426, ISSN: 1477-3155, DOI: 10.1186/s12951-022-01552-0
TIAN CHUTONG, ZHENG SHUNZHE, LIU XINYING, KAMEI KEN-ICHIRO: "Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system", JOURNAL OF NANOBIOTECHNOLOGY, BIOMED CENTRAL, vol. 20, no. 1, 1 December 2022 (2022-12-01), XP093139426, ISSN: 1477-3155, DOI: 10.1186/s12951-022-01552-0
Attorney, Agent or Firm:
NAM & NAM (KR)
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