Title:
MICROFLUIDIC DEVICES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2002029106
Kind Code:
A3
Abstract:
A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality. Velocity independent cytometry methods and apparatuses are also described.
Inventors:
CHOU HOU-PU
EYAL SHULAMIT
FU ANNE Y
QUAKE STEPHEN R
EYAL SHULAMIT
FU ANNE Y
QUAKE STEPHEN R
Application Number:
PCT/US2001/030933
Publication Date:
July 11, 2002
Filing Date:
October 02, 2001
Export Citation:
Assignee:
CALIFORNIA INST OF TECHN (US)
International Classes:
B01L3/00; B81B1/00; F04B11/00; B01L99/00; F04B19/00; F04B43/04; G01N15/14; B81B3/00; G01N30/20; G01N30/32; G01N30/60; (IPC1-7): G01N15/14; F04B19/00; F04B43/04; F04B11/00
Domestic Patent References:
| WO2000057173A1 | 2000-09-28 | |||
| WO1994019609A1 | 1994-09-01 | |||
| WO1999061888A2 | 1999-12-02 |
Foreign References:
| US3537585A | 1970-11-03 | |||
| US4879029A | 1989-11-07 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 006, no. 265 (P - 165) 24 December 1982 (1982-12-24)
Download PDF: