Title:
MICROFLUIDIC SYSTEMS
Document Type and Number:
WIPO Patent Application WO/2009/050512
Kind Code:
A2
Abstract:
This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non- emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).
Inventors:
ABELL CHRIS (GB)
HUCK WILHELM T S (GB)
BRATTON DANIEL (GB)
GRAEME WHYTE (GB)
FIDALGO LUIS M (GB)
HUCK WILHELM T S (GB)
BRATTON DANIEL (GB)
GRAEME WHYTE (GB)
FIDALGO LUIS M (GB)
Application Number:
PCT/GB2008/050944
Publication Date:
April 23, 2009
Filing Date:
October 16, 2008
Export Citation:
Assignee:
CAMBRIDGE ENTPR LTD (GB)
ABELL CHRIS (GB)
HUCK WILHELM T S (GB)
BRATTON DANIEL (GB)
GRAEME WHYTE (GB)
FIDALGO LUIS M (GB)
ABELL CHRIS (GB)
HUCK WILHELM T S (GB)
BRATTON DANIEL (GB)
GRAEME WHYTE (GB)
FIDALGO LUIS M (GB)
International Classes:
B01J19/00; B01L3/00
Domestic Patent References:
| WO2005021151A1 | 2005-03-10 | |||
| WO2007081387A1 | 2007-07-19 | |||
| WO2004071638A2 | 2004-08-26 | |||
| WO1996012541A1 | 1996-05-02 |
Foreign References:
| US20010048637A1 | 2001-12-06 | |||
| US20040219078A1 | 2004-11-04 | |||
| EP1380337A2 | 2004-01-14 | |||
| US20060280029A1 | 2006-12-14 | |||
| US20040211659A1 | 2004-10-28 |
Other References:
LEE, V. CRISTINI; A. P. LEE, LAB CHIP, vol. 4, 2004, pages 292
P. S. DITTRICH; M. JAHNZ; P. SCHWILLE, CHEMBIOCHEM, vol. 6, 2005, pages 811
K. AHN; C. KERBAGE; T. P. HUNT; R. M. WESTERVELT; D. R. LINK; D. A. WEITZ, APPL. PHYS. LETT., vol. 88, 2006, pages 024104
P. S. DITTRICH; K. TACHIKAWA; A. MANZ, ANAL. CHEM., vol. 78, 2006, pages 3887
J. BIBETTE; F. L. CALDERON; P. POULIN, REP. PROG. PHYS., vol. 62, 1999, pages 969
J. S. EOW; M. GHADIRI; A. 0. SHARIF; T. J. WILLIAMS, CHEMICAL ENGINEERING JOURNAL, vol. 84, 2001, pages 173
P. ATTEN, JOURNAL OF ELECTROSTATICS, vol. 30, 1993, pages 259
J. G. KRALJ; M. A. SCHMIDT; K. F. JENSEN, LAB CHIP, vol. 5, 2005, pages 531
C. PRIEST; S. HERMINGHAUS; R. SEEMANN, APPL. PHYS. LETT., vol. 89, 2006, pages 134101
GO TAKEI; ARATA AOTA; AKIHIDE HIBARA; TAKEHIKO KITAMORI; HAENG-BOO KIM: "Phase separation of segmented flow by the photocatalytic wettability patterning and tuning of microchannel surface", ELEVENTH INTERNATIONAL CONFERENCE ON MINIATURIZED SYSTEMS FOR CHEMISTRY AND LIFE SCIENCES, 7 October 2007 (2007-10-07)
P. S. DITTRICH; M. JAHNZ; P. SCHWILLE, CHEMBIOCHEM, vol. 6, 2005, pages 811
K. AHN; C. KERBAGE; T. P. HUNT; R. M. WESTERVELT; D. R. LINK; D. A. WEITZ, APPL. PHYS. LETT., vol. 88, 2006, pages 024104
P. S. DITTRICH; K. TACHIKAWA; A. MANZ, ANAL. CHEM., vol. 78, 2006, pages 3887
J. BIBETTE; F. L. CALDERON; P. POULIN, REP. PROG. PHYS., vol. 62, 1999, pages 969
J. S. EOW; M. GHADIRI; A. 0. SHARIF; T. J. WILLIAMS, CHEMICAL ENGINEERING JOURNAL, vol. 84, 2001, pages 173
P. ATTEN, JOURNAL OF ELECTROSTATICS, vol. 30, 1993, pages 259
J. G. KRALJ; M. A. SCHMIDT; K. F. JENSEN, LAB CHIP, vol. 5, 2005, pages 531
C. PRIEST; S. HERMINGHAUS; R. SEEMANN, APPL. PHYS. LETT., vol. 89, 2006, pages 134101
GO TAKEI; ARATA AOTA; AKIHIDE HIBARA; TAKEHIKO KITAMORI; HAENG-BOO KIM: "Phase separation of segmented flow by the photocatalytic wettability patterning and tuning of microchannel surface", ELEVENTH INTERNATIONAL CONFERENCE ON MINIATURIZED SYSTEMS FOR CHEMISTRY AND LIFE SCIENCES, 7 October 2007 (2007-10-07)
Attorney, Agent or Firm:
MARTIN, Philip (62-68 Hills Road, Cambridge Cambridgeshire CB2 1LA, GB)
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