Title:
MICROGLIA-CONTAINING INTRA-CNS TRANSFER AGENT, CNS DISEASE THERAPEUTIC AGENT INCLUDING SAME, MICROGLIA-INTRODUCED ANIMAL, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2022/113667
Kind Code:
A1
Abstract:
An intra-CNS transfer agent characterized by containing microglia.
Inventors:
KOIZUMI SCHUICHI (JP)
PARAJULI BIJAY (JP)
SHIGETOMI EIJI (JP)
SHINOZAKI YOUICHI (JP)
SAITO HIROKI (JP)
PARAJULI BIJAY (JP)
SHIGETOMI EIJI (JP)
SHINOZAKI YOUICHI (JP)
SAITO HIROKI (JP)
Application Number:
PCT/JP2021/040416
Publication Date:
June 02, 2022
Filing Date:
November 02, 2021
Export Citation:
Assignee:
UNIV YAMANASHI (JP)
International Classes:
A61K35/30; A01K67/027; A61K38/18; A61K38/47; A61P25/00; C12N5/079
Domestic Patent References:
| WO2007035843A2 | 2007-03-29 |
Other References:
DANIELYAN LUSINE, BEER-HAMMER SANDRA, STOLZING ALEXANDRA, SCHÄFER RICHARD, SIEGEL GEORG, FABIAN CLAIRE, KAHLE PHILIPP, BIEDERMANN : "Intranasal Delivery of Bone Marrow-Derived Mesenchymal Stem Cells, Macrophages, and Microglia to the Brain in Mouse Models of Alzheimer's and Parkinson's Disease", CELL TRANSPLANTATION, vol. 23, no. 1_suppl, 1 January 2014 (2014-01-01), US , pages S123 - S139, XP055934563, ISSN: 0963-6897, DOI: 10.3727/096368914X684970
BOHLEN CHRISTOPHER J.; BENNETT F. CHRIS; TUCKER ANDREW F.; COLLINS HANNAH Y.; MULINYAWE SARA B.; BARRES BEN A.: "Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures", NEURON, vol. 94, no. 4, 17 May 2017 (2017-05-17), AMSTERDAM, NL, pages 759, XP085026691, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.04.043
XU ZHEN, RAO YANXIA, HUANG YUBIN, ZHOU TIAN, FENG RUI, XIONG SHANSHAN, YUAN TI-FEI, QIN SHAN, LU YIJIE, ZHOU XIN, LI XIAOYU, QIN B: "Efficient Strategies for Microglia Replacement in the Central Nervous System", CELL REPORTS, vol. 32, no. 6, 1 August 2020 (2020-08-01), US , pages 1 - 22, XP055934594, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2020.108041
ABUD EDSEL M.; RAMIREZ RICARDO N.; MARTINEZ ERIC S.; HEALY LUKE M.; NGUYEN CECILIA H.H.; NEWMAN SEAN A.; YEROMIN ANDRIY V.; SCARFO: "iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases", NEURON, vol. 94, no. 2, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 278, XP029984619, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.03.042
PARAJULI BIJAY, SAITO HIROKI, SHINOZAKI YOUICHI, SHIGETOMI EIJI, MIWA HIROTO, YONEDA SOSUKE, TANIMURA MIKI, OMACHI SHIGEKI, ASAKI : "Transnasal transplantation of human induced pluripotent stem cell‐derived microglia to the brain of immunocompetent mice", GLIA, vol. 69, no. 10, 1 October 2021 (2021-10-01), US , pages 2332 - 2348, XP055934597, ISSN: 0894-1491, DOI: 10.1002/glia.23985
BOHLEN CHRISTOPHER J.; BENNETT F. CHRIS; TUCKER ANDREW F.; COLLINS HANNAH Y.; MULINYAWE SARA B.; BARRES BEN A.: "Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures", NEURON, vol. 94, no. 4, 17 May 2017 (2017-05-17), AMSTERDAM, NL, pages 759, XP085026691, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.04.043
XU ZHEN, RAO YANXIA, HUANG YUBIN, ZHOU TIAN, FENG RUI, XIONG SHANSHAN, YUAN TI-FEI, QIN SHAN, LU YIJIE, ZHOU XIN, LI XIAOYU, QIN B: "Efficient Strategies for Microglia Replacement in the Central Nervous System", CELL REPORTS, vol. 32, no. 6, 1 August 2020 (2020-08-01), US , pages 1 - 22, XP055934594, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2020.108041
ABUD EDSEL M.; RAMIREZ RICARDO N.; MARTINEZ ERIC S.; HEALY LUKE M.; NGUYEN CECILIA H.H.; NEWMAN SEAN A.; YEROMIN ANDRIY V.; SCARFO: "iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases", NEURON, vol. 94, no. 2, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 278, XP029984619, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.03.042
PARAJULI BIJAY, SAITO HIROKI, SHINOZAKI YOUICHI, SHIGETOMI EIJI, MIWA HIROTO, YONEDA SOSUKE, TANIMURA MIKI, OMACHI SHIGEKI, ASAKI : "Transnasal transplantation of human induced pluripotent stem cell‐derived microglia to the brain of immunocompetent mice", GLIA, vol. 69, no. 10, 1 October 2021 (2021-10-01), US , pages 2332 - 2348, XP055934597, ISSN: 0894-1491, DOI: 10.1002/glia.23985
Attorney, Agent or Firm:
HIROTA, Koichi et al. (JP)
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