Title:
MICROORGANISM CAPABLE OF ENHANCING LACTIC ACID PRODUCTION AND METHOD FOR PRODUCING LACTIC ACID USING SAME
Document Type and Number:
WIPO Patent Application WO/2015/170914
Kind Code:
A1
Abstract:
The present invention relates to a lactic acid-producing microorganism of Saccharomyces sp. having a reduced pyruvate decarboxylase (PDC) activity and enhanced aldehyde dehydrogenase (ALD) and acetyl-CoA synthetase (ACS) activities, and a method for producing a lactic acid from a medium of the microorganism by culturing the microorganism.
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Inventors:
YANG EUN BIN (KR)
LEE TAE HEE (KR)
KIM SEON HYE (KR)
SONG GYU HYEON (KR)
HA CHEOL WOONG (KR)
NA KYUNG SU (KR)
YANG YOUNG LYEOL (KR)
KANG MIN SUN (KR)
LEE HYO HYOUNG (KR)
LEE TAE HEE (KR)
KIM SEON HYE (KR)
SONG GYU HYEON (KR)
HA CHEOL WOONG (KR)
NA KYUNG SU (KR)
YANG YOUNG LYEOL (KR)
KANG MIN SUN (KR)
LEE HYO HYOUNG (KR)
Application Number:
PCT/KR2015/004600
Publication Date:
November 12, 2015
Filing Date:
May 08, 2015
Export Citation:
Assignee:
CJ CHEILJEDANG CORP (KR)
International Classes:
C12N1/19; C12N15/52; C12P7/56; C12R1/865
Domestic Patent References:
| WO2013052604A1 | 2013-04-11 |
Foreign References:
| KR20140001165A | 2014-01-06 | |||
| KR20020048910A | 2002-06-24 | |||
| KR20130126809A | 2013-11-21 | |||
| KR20000067653A | 2000-11-25 | |||
| KR20130098603A | 2013-09-05 | |||
| US20120021421A1 | 2012-01-26 | |||
| US20100248233A1 | 2010-09-30 | |||
| US20060148050A1 | 2006-07-06 |
Other References:
TOKUHIRO, KENRO. ET AL.: "Double mutation of the PDC1 and ADH1 genes improves lactate production in the yeast Saccharomyces cerevisiae expressing the bovine lactate dehydrogenase gene .", APPL MICROBIOL BIOTECHNOL., vol. 82, 2009, pages 883 - 890, XP019705475
ISHIDA, NOBUHIRO. ET AL.: "The Effect of Pyruvate Decarboxylase Gene Knockout in Saccharomyces cerevisiae on L-Lactic Acid Production.", BIOSCI BIOTECHNOL BIOCHEM, vol. 70, no. 5, 2006, pages 1148 - 1153, XP008129166
BIANCHI, M. MICHELE. ET AL.: "Efficient Homolactic Fermentation by Kluyveromyces lactis Strains Defective in Pyruvate Utilization and Transformed with the Heterologous LDH Gene .", APPL ENVIRON MICROBIOL., vol. 67, no. 12, 2001, pages 5621 - 5625, XP002236026
PING LIU ET AL.: "Metabolic engineering of biocatalysts for carboxylic acids production.", CSBJ., vol. 3, no. Issue, 4., 2012, pages 1 - 9, XP055177846
APPL MICROBIOL BIOTECHNOL., vol. 82, no. 5, 2009, pages 883 - 90
J BACTERIOL., vol. 172, no. 2, 1990, pages 678 - 685
BIOSCI BIOTECHNOL BIOCHEM., vol. 70, no. 5, 2006, pages 1148 - 1153
CURR GENET., vol. 43, no. 3, 2003, pages 139 - 160
LEE TH ET AL., J. MICROBIOL. BIOTECHNOL., vol. 16, no. 6, 2006, pages 979 - 982
LEE T. H. ET AL.: "Development of reusable split URA3-marked knockout vectors for budding yeast, Saccharomyces cerevisiae", J MICROBIOL BIOTECHNOL, vol. 16, 2006, pages 979 - 982
ISHIDA, NOBUHIRO. ET AL.: "The Effect of Pyruvate Decarboxylase Gene Knockout in Saccharomyces cerevisiae on L-Lactic Acid Production.", BIOSCI BIOTECHNOL BIOCHEM, vol. 70, no. 5, 2006, pages 1148 - 1153, XP008129166
BIANCHI, M. MICHELE. ET AL.: "Efficient Homolactic Fermentation by Kluyveromyces lactis Strains Defective in Pyruvate Utilization and Transformed with the Heterologous LDH Gene .", APPL ENVIRON MICROBIOL., vol. 67, no. 12, 2001, pages 5621 - 5625, XP002236026
PING LIU ET AL.: "Metabolic engineering of biocatalysts for carboxylic acids production.", CSBJ., vol. 3, no. Issue, 4., 2012, pages 1 - 9, XP055177846
APPL MICROBIOL BIOTECHNOL., vol. 82, no. 5, 2009, pages 883 - 90
J BACTERIOL., vol. 172, no. 2, 1990, pages 678 - 685
BIOSCI BIOTECHNOL BIOCHEM., vol. 70, no. 5, 2006, pages 1148 - 1153
CURR GENET., vol. 43, no. 3, 2003, pages 139 - 160
LEE TH ET AL., J. MICROBIOL. BIOTECHNOL., vol. 16, no. 6, 2006, pages 979 - 982
LEE T. H. ET AL.: "Development of reusable split URA3-marked knockout vectors for budding yeast, Saccharomyces cerevisiae", J MICROBIOL BIOTECHNOL, vol. 16, 2006, pages 979 - 982
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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