Title:
MICROORGANISM FOR CONVERTING CARBON DIOXIDE TO ALIPHATIC CARBOXYLIC ACIDS VIA FORMIC ACID INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2013/011292
Kind Code:
A3
Abstract:
The invention relates to a micro-organism comprising a hydrogenase enzyme system which is capable of converting carbon dioxide into formic acid and a second enzyme system which is capable of converting formic acid into aliphatic carboxylic acids having a chain length of five or more carbon atoms. Also described are various methods for producing oil, as well as other aspects of the invention.
Inventors:
FINNEGAN IRENE (GB)
Application Number:
PCT/GB2012/051690
Publication Date:
April 25, 2013
Filing Date:
July 13, 2012
Export Citation:
Assignee:
VERDANT BIOPRODUCTS LTD (GB)
FINNEGAN IRENE (GB)
FINNEGAN IRENE (GB)
International Classes:
C12N1/00; C12N9/00; C12P7/40
Domestic Patent References:
| WO2008070561A1 | 2008-06-12 | |||
| WO2010115054A2 | 2010-10-07 |
Foreign References:
| US20100151543A1 | 2010-06-17 |
Other References:
TANAKA K ET AL: "Separation of aliphatic carboxylic acids by ion-exclusion chromatography using a weak-acid eluent", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V, NL, vol. 361, 1 January 1986 (1986-01-01), pages 151 - 160, XP026476355, ISSN: 0021-9673, [retrieved on 19860101], DOI: 10.1016/S0021-9673(01)86902-8
CLEENWERCK I ET AL: "Polyphasic taxonomy of acetic acid bacteria: An overview of the currently applied methodology", INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 125, no. 1, 30 June 2008 (2008-06-30), pages 2 - 14, XP022709793, ISSN: 0168-1605, [retrieved on 20071214], DOI: 10.1016/J.IJFOODMICRO.2007.04.017
DATABASE UniProt [online] 13 October 2009 (2009-10-13), "SubName: Full=Formate dehydrogenase gamma subunit;", XP002691298, retrieved from EBI accession no. UNIPROT:C7K810 Database accession no. C7K810
TISHKOV V I ET AL: "Catalytic mechanism and application of formate dehydrogenase", BIOCHEMISTRY (MOSCOW), KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 69, no. 11, 1 November 2004 (2004-11-01), pages 1252 - 1267, XP019294413, ISSN: 1608-3040
T. REDA ET AL: "Reversible interconversion of carbon dioxide and formate by an electroactive enzyme", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 105, no. 31, 5 August 2008 (2008-08-05), pages 10654 - 10658, XP055051452, ISSN: 0027-8424, DOI: 10.1073/pnas.0801290105
BRYAN R. CRABLE ET AL: "Formate Formation and Formate Conversion in Biological Fuels Production", ENZYME RESEARCH, vol. 41, no. 1, 1 January 2011 (2011-01-01), pages 100 - 8, XP055051457, ISSN: 2090-0406, DOI: 10.1111/j.1751-7915.2007.00003.x
LU X ET AL: "Overproduction of free fatty acids in E. coli: Implications for biodiesel production", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 10, no. 6, 1 November 2008 (2008-11-01), pages 333 - 339, XP025800635, ISSN: 1096-7176, [retrieved on 20080909], DOI: 10.1016/J.YMBEN.2008.08.006
CHEMLER JOSEPH A ET AL: "Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae", MICROBIAL CELL FACTORIES, BIOMED CENTRAL, LONDON, NL, vol. 5, no. 1, 23 May 2006 (2006-05-23), pages 20, XP021017781, ISSN: 1475-2859, DOI: 10.1186/1475-2859-5-20
CLEENWERCK I ET AL: "Polyphasic taxonomy of acetic acid bacteria: An overview of the currently applied methodology", INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 125, no. 1, 30 June 2008 (2008-06-30), pages 2 - 14, XP022709793, ISSN: 0168-1605, [retrieved on 20071214], DOI: 10.1016/J.IJFOODMICRO.2007.04.017
DATABASE UniProt [online] 13 October 2009 (2009-10-13), "SubName: Full=Formate dehydrogenase gamma subunit;", XP002691298, retrieved from EBI accession no. UNIPROT:C7K810 Database accession no. C7K810
TISHKOV V I ET AL: "Catalytic mechanism and application of formate dehydrogenase", BIOCHEMISTRY (MOSCOW), KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 69, no. 11, 1 November 2004 (2004-11-01), pages 1252 - 1267, XP019294413, ISSN: 1608-3040
T. REDA ET AL: "Reversible interconversion of carbon dioxide and formate by an electroactive enzyme", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 105, no. 31, 5 August 2008 (2008-08-05), pages 10654 - 10658, XP055051452, ISSN: 0027-8424, DOI: 10.1073/pnas.0801290105
BRYAN R. CRABLE ET AL: "Formate Formation and Formate Conversion in Biological Fuels Production", ENZYME RESEARCH, vol. 41, no. 1, 1 January 2011 (2011-01-01), pages 100 - 8, XP055051457, ISSN: 2090-0406, DOI: 10.1111/j.1751-7915.2007.00003.x
LU X ET AL: "Overproduction of free fatty acids in E. coli: Implications for biodiesel production", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 10, no. 6, 1 November 2008 (2008-11-01), pages 333 - 339, XP025800635, ISSN: 1096-7176, [retrieved on 20080909], DOI: 10.1016/J.YMBEN.2008.08.006
CHEMLER JOSEPH A ET AL: "Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae", MICROBIAL CELL FACTORIES, BIOMED CENTRAL, LONDON, NL, vol. 5, no. 1, 23 May 2006 (2006-05-23), pages 20, XP021017781, ISSN: 1475-2859, DOI: 10.1186/1475-2859-5-20
Attorney, Agent or Firm:
WILSON, Justin et al. (4 More London Riverside, London SE1 2AU, GB)
Download PDF: