Title:
MICROORGANISM HAVING ENHANCED L-BRANCHED CHAIN AMINO ACID PRODUCTION ABILITY AND METHOD FOR PRODUCING L-BRANCHED CHAIN AMINO ACID BY USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/235855
Kind Code:
A1
Abstract:
The present invention relates to an L-branched chain amino acid producing microorganism having enhanced activity of an acetic acid metabolism regulator A and a method for producing an L-branched chain amino acid at high efficiency by culturing the microorganism, wherein the activity enhancement of the acetic acid metabolism regulator A is achieved by introducing mutation in the promoter sequence of a gene that encodes the acetic acid metabolism regulator A.
Inventors:
YOON BYOUNG HOON (KR)
KIM SEON HYE (KR)
CHANG JIN SOOK (KR)
KIM JU-YEON (KR)
CHOI SUN HYOUNG (KR)
KIM KYUNGRIM (KR)
KIM JU EUN (KR)
KIM HYUNG JOON (KR)
KIM SEON HYE (KR)
CHANG JIN SOOK (KR)
KIM JU-YEON (KR)
CHOI SUN HYOUNG (KR)
KIM KYUNGRIM (KR)
KIM JU EUN (KR)
KIM HYUNG JOON (KR)
Application Number:
PCT/KR2021/006262
Publication Date:
November 25, 2021
Filing Date:
May 20, 2021
Export Citation:
Assignee:
CJ CHEILJEDANG CORP (KR)
International Classes:
C12N15/77; C07K14/34; C12P13/06
Foreign References:
| KR101947945B1 | 2019-02-13 | |||
| JP2002191370A | 2002-07-09 | |||
| US20040229305A1 | 2004-11-18 | |||
| US10316297B2 | 2019-06-11 | |||
| US10526586B2 | 2020-01-07 | |||
| US10072278B2 | 2018-09-11 | |||
| US7662943B2 | 2010-02-16 | |||
| US10584338B2 | 2020-03-10 | |||
| US10273491B2 | 2019-04-30 | |||
| KR101117022B1 | 2012-03-16 | |||
| KR100924065B1 | 2009-10-27 | |||
| KR20080033001A | 2008-04-16 |
Other References:
ZHANG HAILING, LI YANYAN, WANG CHENHUI, WANG XIAOYUAN: "Understanding the high l-valine production in Corynebacterium glutamicum VWB-1 using transcriptomics and proteomics", SCIENTIFIC REPORTS, vol. 3632, no. 8, 1 December 2018 (2018-12-01), XP055869154, DOI: 10.1038/s41598-018-21926-5
LANGE C ET AL: "Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 69, no. 5, 1 May 2003 (2003-05-01), US , pages 2521 - 2532, XP002401827, ISSN: 0099-2240, DOI: 10.1128/AEM.69.5.2521-2532.2003
SITNICKA ET AL.: "Functional Analysis of Genes", ADVANCES IN CELL BIOLOGY, vol. 2, 2010, pages 1 - 16
SAMBROOK ET AL.: "Molecular Cloning", 2012
SMITHWATERMAN, ADV. APPL. MATH, vol. 2, 1981, pages 482
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL., TRENDS GENET, vol. 16, 2000, pages 276 - 277
DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 387
ATSCHUL, S. F ET AL., J MOLEC BIOL, vol. 215, 1990, pages 403
"Guide to Huge Computers", 1994, ACADEMIC PRESS
CARILLO ET AL., SIAM J APPLIED MATH, vol. 48, 1988, pages 1073
NEEDLEMAN ET AL., J MOL BIOL., vol. 48, 1970, pages 443
GRIBSKOV ET AL., NUCL. ACIDS RES., vol. 14, 1986, pages 6745
"Atlas Of Protein Sequence and Structure", 1979, NATIONAL BIOMEDICAL RESEARCH FOUNDATION, pages: 353 - 358
VAN DER REST ET AL., APPL MICROBIOL BIOTECHNOL, vol. 52, 1999, pages 541 - 545
SAMBROOK ET AL.: "Molecular Cloning, a Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORIES
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 19, June 2014 (2014-06-01), pages 456 - 467
LANGE C ET AL: "Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 69, no. 5, 1 May 2003 (2003-05-01), US , pages 2521 - 2532, XP002401827, ISSN: 0099-2240, DOI: 10.1128/AEM.69.5.2521-2532.2003
SITNICKA ET AL.: "Functional Analysis of Genes", ADVANCES IN CELL BIOLOGY, vol. 2, 2010, pages 1 - 16
SAMBROOK ET AL.: "Molecular Cloning", 2012
SMITHWATERMAN, ADV. APPL. MATH, vol. 2, 1981, pages 482
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL., TRENDS GENET, vol. 16, 2000, pages 276 - 277
DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 387
ATSCHUL, S. F ET AL., J MOLEC BIOL, vol. 215, 1990, pages 403
"Guide to Huge Computers", 1994, ACADEMIC PRESS
CARILLO ET AL., SIAM J APPLIED MATH, vol. 48, 1988, pages 1073
NEEDLEMAN ET AL., J MOL BIOL., vol. 48, 1970, pages 443
GRIBSKOV ET AL., NUCL. ACIDS RES., vol. 14, 1986, pages 6745
"Atlas Of Protein Sequence and Structure", 1979, NATIONAL BIOMEDICAL RESEARCH FOUNDATION, pages: 353 - 358
VAN DER REST ET AL., APPL MICROBIOL BIOTECHNOL, vol. 52, 1999, pages 541 - 545
SAMBROOK ET AL.: "Molecular Cloning, a Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORIES
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 19, June 2014 (2014-06-01), pages 456 - 467
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY AND LAW (KR)
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