Title:
MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2013/184602
Kind Code:
A3
Abstract:
The invention provides non-naturally occurring microbial organisms having a 4- hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4- hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4- hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.
Inventors:
BURK MARK J
PHARKYA PRITI (US)
BURGARD ANTHONY P (US)
VAN DIEN STEPHEN J (US)
OSTERHOUT ROBIN E (US)
TRAWICK JOHN D (US)
KUCHINSKAS MICHAEL P (US)
STEER BRIAN (US)
PHARKYA PRITI (US)
BURGARD ANTHONY P (US)
VAN DIEN STEPHEN J (US)
OSTERHOUT ROBIN E (US)
TRAWICK JOHN D (US)
KUCHINSKAS MICHAEL P (US)
STEER BRIAN (US)
Application Number:
PCT/US2013/043954
Publication Date:
January 30, 2014
Filing Date:
June 03, 2013
Export Citation:
Assignee:
GENOMATICA INC (US)
BURK MARK J
BURK MARK J
International Classes:
C12P7/52; C12N1/20; C12N1/21
Domestic Patent References:
| WO2008115840A2 | 2008-09-25 |
Foreign References:
| US20110217742A1 | 2011-09-08 |
Other References:
KHALAMEYZER, V ET AL.: "Screening, Nucleotide Sequence, And Biochemical Characterization Of An Esterase From Pseudomonas fluorescens With High Activity Towards Lactone.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY., vol. 65, no. 2, February 1999 (1999-02-01), pages 477 - 482, XP008089566
DATABASE UNIPROT [online] December 2008 (2008-12-01), READ, TD ET AL.: "Annotation Of The Yersinia Intermedia ATCC 29909 Genome.", XP003034309, Database accession no. C4SZW2
DATABASE UNIPROT [online] December 2008 (2008-12-01), READ, TD ET AL.: "Annotation Of The Yersinia Intermedia ATCC 29909 Genome.", XP003034309, Database accession no. C4SZW2
Attorney, Agent or Firm:
GAY, David, A. et al. (222 East 41st StreetNew York, NY, US)
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