MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS

Title:

MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/2014/176514

Kind Code:

A3

Abstract:

The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.

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Inventors:

PHARKYA PRITI (US)
BURGARD ANTHONY P (US)
VAN DIEN STEPHEN J (US)
OSTERHOUT ROBIN E (US)
BURK MARK J (US)
TRAWICK JOHN D (US)
KUCHINSKAS MICHAEL P (US)
STEER BRIAN (US)

Application Number:

PCT/US2014/035475

Publication Date:

January 15, 2015

Filing Date:

April 25, 2014

Export Citation:

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Assignee:

GENOMATICA INC (US)

International Classes:

C07H21/04; C12N9/10; C12N9/14; C12N15/00; C12P7/16; C12P21/06

Foreign References:

CN102965401A	2013-03-13
US20130029381A1	2013-01-31

Other References: