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Title:
MICROORGANISMS FOR PRODUCING N-PROPANOL 1, 3-PROPANEDIOL, 1,2-PROPANEDIOL OR GLYCEROL AND METHODS RELATED THERETO
Document Type and Number:
WIPO Patent Application WO/2012/177599
Kind Code:
A3
Abstract:
Provided herein is a non-naturally occurring microbial organism having a reductive TCA or Wood-Ljungdahl pathway and comprising at least one exogenous nucleic acid encoding said pathway enzymes expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. Also provided herein is a method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, and can include culturing this organism for a sufficient period of time to produce a product.

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Inventors:
BURGARD ANTHONY P (US)
OSTERHOUT ROBIN E (US)
SUN JUN (US)
PHARKYA PRITI (US)
Application Number:
PCT/US2012/043086
Publication Date:
February 21, 2013
Filing Date:
June 19, 2012
Export Citation:
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Assignee:
GENOMATICA INC (US)
BURGARD ANTHONY P (US)
OSTERHOUT ROBIN E (US)
SUN JUN (US)
PHARKYA PRITI (US)
International Classes:
C12P7/04; C12N1/21
Domestic Patent References:
WO2011031897A12011-03-17
Foreign References:
US20090191599A12009-07-30
US20100323418A12010-12-23
US20090148914A12009-06-11
Attorney, Agent or Firm:
GAY, David, A. et al. (222 East 41st StreetNew York, NY, US)
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