Title:
MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL
Document Type and Number:
WIPO Patent Application WO/2010/030711
Kind Code:
A3
Abstract:
The invention provides non- naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
Inventors:
BURK MARK J (US)
BURGARD ANTHONY P (US)
OSTERHOUT ROBIN E (US)
SUN JUN (US)
BURGARD ANTHONY P (US)
OSTERHOUT ROBIN E (US)
SUN JUN (US)
Application Number:
PCT/US2009/056415
Publication Date:
October 07, 2010
Filing Date:
September 09, 2009
Export Citation:
Assignee:
GENOMATICA INC (US)
BURK MARK J (US)
BURGARD ANTHONY P (US)
OSTERHOUT ROBIN E (US)
SUN JUN (US)
BURK MARK J (US)
BURGARD ANTHONY P (US)
OSTERHOUT ROBIN E (US)
SUN JUN (US)
International Classes:
C12P1/04; C12P7/16
Domestic Patent References:
| WO2000061763A2 | 2000-10-19 | |||
| WO2009094485A1 | 2009-07-30 |
Foreign References:
| US20070190605A1 | 2007-08-16 | |||
| US20080182308A1 | 2008-07-31 | |||
| US20080138870A1 | 2008-06-12 | |||
| JPS62285779A | 1987-12-11 | |||
| US20090047719A1 | 2009-02-19 |
Other References:
GERHARDT ET AL.: "Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA.", ARCH. MICROBIOL., vol. 174, no. 3, 2000, pages 189 - 199, XP008109904
CKINLAY ET AL.: "Prospects for a bio-based succinate industry.", APPL. MICROBIOL. BIOTECHNOL., vol. 76, no. 4, 2007, pages 727 - 740, XP019538718
TAKIGAWA ET AL.: "Probabilistic path ranking based on adjacent pairwise coexpression for metabolic transcripts analysis.", BIOINFORMATICS., vol. 24, no. 2, 15 January 2008 (2008-01-15), pages 250 - 257, XP008131673
JEWELL ET AL.: "Bioconversion of Propionic, Valeric, and 4-Hydroxybutyric Acids into the Corresponding Alcohols by Clostridium acetobutylicum NRRL 537.", CURR. MICROBIOL., vol. 13, 1986, pages 215 - 219, XP008139685
CUKALOVIC ET AL.: "Feasibility of production method for succinic acid derivatives: a marriage of renewable resources and chemical technology.", BIOFUELS BIOPROD. BIOREF., vol. 2, 13 October 2008 (2008-10-13), pages 505 - 529, XP008139686
FEIST ET AL.: "The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli.", NAT. BIOTECHNOL., vol. 26, no. 6, June 2008 (2008-06-01), pages 659 - 667, XP008139687
WANG ET AL.: "Screening microorganisms for utilization of furfural and possible intermediates in its degradative pathway.", BIOTECHNOL. LETT., vol. 16, no. 9, 1994, pages 977 - 982, XP008139688
OKINO ET AL.: "An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain.", APPL. MICROBIOL. BIOTECHNOL., vol. 81, no. 3, 6 September 2008 (2008-09-06), pages 459 - 464, XP019654155
CKINLAY ET AL.: "Prospects for a bio-based succinate industry.", APPL. MICROBIOL. BIOTECHNOL., vol. 76, no. 4, 2007, pages 727 - 740, XP019538718
TAKIGAWA ET AL.: "Probabilistic path ranking based on adjacent pairwise coexpression for metabolic transcripts analysis.", BIOINFORMATICS., vol. 24, no. 2, 15 January 2008 (2008-01-15), pages 250 - 257, XP008131673
JEWELL ET AL.: "Bioconversion of Propionic, Valeric, and 4-Hydroxybutyric Acids into the Corresponding Alcohols by Clostridium acetobutylicum NRRL 537.", CURR. MICROBIOL., vol. 13, 1986, pages 215 - 219, XP008139685
CUKALOVIC ET AL.: "Feasibility of production method for succinic acid derivatives: a marriage of renewable resources and chemical technology.", BIOFUELS BIOPROD. BIOREF., vol. 2, 13 October 2008 (2008-10-13), pages 505 - 529, XP008139686
FEIST ET AL.: "The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli.", NAT. BIOTECHNOL., vol. 26, no. 6, June 2008 (2008-06-01), pages 659 - 667, XP008139687
WANG ET AL.: "Screening microorganisms for utilization of furfural and possible intermediates in its degradative pathway.", BIOTECHNOL. LETT., vol. 16, no. 9, 1994, pages 977 - 982, XP008139688
OKINO ET AL.: "An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain.", APPL. MICROBIOL. BIOTECHNOL., vol. 81, no. 3, 6 September 2008 (2008-09-06), pages 459 - 464, XP019654155
Attorney, Agent or Firm:
CADENA, Deborah, L. et al. (Will & Emery LLP11682 El Camino Real,Suite 40, San Diego CA, US)
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