Title:
MICROPARTICLES AND METHODS FOR DELIVERY OF RECOMBINANT VIRAL VACCINES
Document Type and Number:
WIPO Patent Application WO2002092132
Kind Code:
A3
Abstract:
Disclosed is a viral vector conjugated to a microparticle, wherein the viral vector comprises a polynucleotide encoding a heterologous polypeptide. Conjugation of the viral vector to the microparticle results in a dramatic increase in the efficacy of the elicited immune response. Also disclosed is a method for delivering a polynucleotide to a cell comprising contacting the cell with a viral vector of the invention. In a preferred embodiment, the cell is an antigen-presenting cell, such as a dendritic cell. The invention further provides a vaccine comprising a viral vector of the invention. The invention thus provides a method for delivering a polynucleotide to a subject, a method of stimulating an immune response in a subject, a method of treating cancer in a subject, a method of inhibiting tumor growth in a subject, and a method of treating an infection in a subject.
Inventors:
HURAL JOHN
JOHNSON MARK E
SPIES A GREGORY
JOHNSON MARK E
SPIES A GREGORY
Application Number:
PCT/US2002/000235
Publication Date:
May 30, 2003
Filing Date:
January 07, 2002
Export Citation:
Assignee:
CORIXA CORP (US)
International Classes:
C12N15/861; A61K39/00; (IPC1-7): C12N15/87; A61K47/48; A61K48/00; A61K39/04
Domestic Patent References:
| WO1998031398A1 | 1998-07-23 |
Other References:
BEER SJ, MATTHEWS CB, STEIN CS ROSS BD HILFINGER JM DAVIDSON BL: "Poly (lactic-glycolic) acid copolymer encapsulation of recombinant adenovirus reduces immunogenicity in vivo", GENE THERAPY, vol. 5, no. 6, 1 June 1998 (1998-06-01), pages 740 - 746, XP008013481
MATTHEWS C B ET AL: "POLY-L-LYSINE IMPROVES GENE TRANSFER WITH ADENOVIRUS FORMULATED IN PLGA MICROSPHERES", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 6, no. 9, September 1999 (1999-09-01), pages 1558 - 1564, XP000971877, ISSN: 0969-7128
FOOKS AR, SHARPE SA, SHALLCROSS JA, CLEGG JC CRANAGE MP: "Induction of immunity using oral DNA vaccines expressing the measles virus nucleocapsid protein", DEVELOPMENTS IN BIOLOGICALS, vol. 104, 2000, pages 65 - 71, XP008013462
BILBAO G ET AL: "TARGETED ADENOVIRAL VECTORS FOR CANCER GENE THERAPY", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRING ST., NY, US, vol. 451, 1998, pages 365 - 374, XP000877370, ISSN: 0065-2598
MATTHEWS C B ET AL: "POLY-L-LYSINE IMPROVES GENE TRANSFER WITH ADENOVIRUS FORMULATED IN PLGA MICROSPHERES", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 6, no. 9, September 1999 (1999-09-01), pages 1558 - 1564, XP000971877, ISSN: 0969-7128
FOOKS AR, SHARPE SA, SHALLCROSS JA, CLEGG JC CRANAGE MP: "Induction of immunity using oral DNA vaccines expressing the measles virus nucleocapsid protein", DEVELOPMENTS IN BIOLOGICALS, vol. 104, 2000, pages 65 - 71, XP008013462
BILBAO G ET AL: "TARGETED ADENOVIRAL VECTORS FOR CANCER GENE THERAPY", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRING ST., NY, US, vol. 451, 1998, pages 365 - 374, XP000877370, ISSN: 0065-2598
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