Title:
MICRORNA BIOMARKERS FOR OVARIAN CANCER
Document Type and Number:
WIPO Patent Application WO/2015/095862
Kind Code:
A3
Abstract:
A method of diagnosing ovarian cancer in a subject is described that includes identifying the expression level of at least one diagnostic miRNA in a biological sample from the subject, comparing the expression level of the at least one diagnostic miRNA to control expression levels, and diagnosing the subject as having or being at an increased risk of having ovarian cancer if the subject has a changed expression level of the one or more diagnostic miRNA. The method also includes a method of providing a prognosis for a subject having ovarian cancer, and kits for carrying out a diagnosis or prognosis of ovarian cancer using miRNA.
Inventors:
LEE ANNETTE (US)
SHAPIRA IULIANA (US)
SHAPIRA IULIANA (US)
Application Number:
PCT/US2014/071840
Publication Date:
September 03, 2015
Filing Date:
December 22, 2014
Export Citation:
Assignee:
THE FEINSTEIN INST MEDICAL RES (US)
International Classes:
C12Q1/68; A61K33/243
Domestic Patent References:
| WO2005078139A2 | 2005-08-25 |
Other References:
Z. LIU ET AL: "miR-106a Represses the Rb Tumor Suppressor p130 to Regulate Cellular Proliferation and Differentiation in High-Grade Serous Ovarian Carcinoma", MOLECULAR CANCER RESEARCH, vol. 11, no. 11, 1 November 2013 (2013-11-01), pages 1314 - 1325, XP055185795, ISSN: 1541-7786, DOI: 10.1158/1541-7786.MCR-13-0131
SHAH PARAG P ET AL: "Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer", JOURNAL OF OVARIAN RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 2, no. 1, 27 August 2009 (2009-08-27), pages 11, XP021060949, ISSN: 1757-2215, DOI: 10.1186/1757-2215-2-11
HUANCHUN YING ET AL: "microRNA and transcription factor mediated regulatory network for ovarian cancer", TUMOR BIOLOGY, vol. 34, no. 5, 29 August 2013 (2013-08-29), pages 3219 - 3225, XP055185803, ISSN: 1010-4283, DOI: 10.1007/s13277-013-0892-y
SHAH PARAG P ET AL: "Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer", JOURNAL OF OVARIAN RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 2, no. 1, 27 August 2009 (2009-08-27), pages 11, XP021060949, ISSN: 1757-2215, DOI: 10.1186/1757-2215-2-11
HUANCHUN YING ET AL: "microRNA and transcription factor mediated regulatory network for ovarian cancer", TUMOR BIOLOGY, vol. 34, no. 5, 29 August 2013 (2013-08-29), pages 3219 - 3225, XP055185803, ISSN: 1010-4283, DOI: 10.1007/s13277-013-0892-y
Attorney, Agent or Firm:
RUSSELL, Raymond N. (Sundheim Covell & Tummino L.L.P.,1300 East Ninth Street,Suite 170, Cleveland Ohio, US)
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