Title:
MICRORNA AND PHARMACEUTICAL COMPOSITION HAVING A DERIVATIVE THEREOF AS THE ACTIVE COMPONENT
Document Type and Number:
WIPO Patent Application WO/2019/107487
Kind Code:
A1
Abstract:
A pharmaceutical composition used in treatment of tumors is provided that is based on a new concept that starts from the relation between cancer and BRD4. This pharmaceutical composition contains a polynucleotide having a base sequence represented by sequence number 1, sequence number 2, sequence number 4 or sequence number 5, and is used in the treatment of tumors.
Inventors:
INAZAWA JOHJI (JP)
GEN YASUYUKI (JP)
MURAMATSU TOMOKI (JP)
TONOUCHI ERINA (JP)
GEN YASUYUKI (JP)
MURAMATSU TOMOKI (JP)
TONOUCHI ERINA (JP)
Application Number:
PCT/JP2018/043966
Publication Date:
June 06, 2019
Filing Date:
November 29, 2018
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
International Classes:
A61K31/713; A61K48/00; A61P35/00; A61P43/00
Foreign References:
| JP2016140251A | 2016-08-08 |
Other References:
HE, TIANPENG ET AL.: "MiR-137 silencing of BRD4 suppresses oral squamous cell carcinoma cells proliferation, migration and invasion", INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, vol. 10, no. 1, 2017, pages 409 - 416, XP055608035
WANG, YONGHUI ET AL.: "Hsa-miR-599 suppresses the migration and invasion by targeting BRD4 in breast cancer", ONCOLOGY LETTERS, vol. 14, no. 3, 21 July 2017 (2017-07-21), pages 3455 - 3462, XP055615192
PATHAK, EKTA ET AL.: "Deciphering the Role of microRNAs in BRD4-NUT Fusion Gene Induced NUT Midline Carcinoma", BIOINFORMATION, vol. 13, no. 6, June 2017 (2017-06-01), pages 209 - 213, XP055615195
TONOUCHI, ERINA ET AL.: "Function-based microRNA library screening identified a novel tumor suppressive miRNA regulating BRD4", A BET FAMILY GENE- ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION, vol. 76, no. P-2055, September 2017 (2017-09-01), pages 597
MURAMATSU, TOMOKI ET AL.: "Abstract LB-385: miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein", CANCER RESEARCH, vol. 78, no. 13, July 2018 (2018-07-01), pages 1 - 4, XP055615200, Retrieved from the Internet [retrieved on 20181217]
WANG, YONGHUI ET AL.: "Hsa-miR-599 suppresses the migration and invasion by targeting BRD4 in breast cancer", ONCOLOGY LETTERS, vol. 14, no. 3, 21 July 2017 (2017-07-21), pages 3455 - 3462, XP055615192
PATHAK, EKTA ET AL.: "Deciphering the Role of microRNAs in BRD4-NUT Fusion Gene Induced NUT Midline Carcinoma", BIOINFORMATION, vol. 13, no. 6, June 2017 (2017-06-01), pages 209 - 213, XP055615195
TONOUCHI, ERINA ET AL.: "Function-based microRNA library screening identified a novel tumor suppressive miRNA regulating BRD4", A BET FAMILY GENE- ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION, vol. 76, no. P-2055, September 2017 (2017-09-01), pages 597
MURAMATSU, TOMOKI ET AL.: "Abstract LB-385: miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein", CANCER RESEARCH, vol. 78, no. 13, July 2018 (2018-07-01), pages 1 - 4, XP055615200, Retrieved from the Internet
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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