Title:
MICRORNAS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/093305
Kind Code:
A3
Abstract:
The present invention provides novel microRNAs and their uses.
Inventors:
PENDERGRAST P SHANNON (US)
PENDERGRAST R SCOTT (US)
PENDERGRAST J STEPHEN (US)
MARKOWSKA ANNA IRMINA (US)
HUETTIG FRED R (US)
PENDERGRAST R SCOTT (US)
PENDERGRAST J STEPHEN (US)
MARKOWSKA ANNA IRMINA (US)
HUETTIG FRED R (US)
Application Number:
PCT/US2013/074055
Publication Date:
August 14, 2014
Filing Date:
December 10, 2013
Export Citation:
Assignee:
YMIR GENOMICS LLC (US)
International Classes:
C12N15/113; A61K31/7088; A61P1/16; G16B30/10
Foreign References:
| EP2497835A2 | 2012-09-12 |
Other References:
RAJESH C. MIRANDA ET AL: "MicroRNAs: Master Regulators of Ethanol Abuse and Toxicity?", ALCOHOLISM: CLINICAL & EXPERIMENTAL RESEARCH, vol. 34, no. 4, 26 January 2010 (2010-01-26), pages 575 - 587, XP055109394, ISSN: 0145-6008, DOI: 10.1111/j.1530-0277.2009.01126.x
FANYIN MENG ET AL: "Epigenetic Regulation of miR-34a Expression in Alcoholic Liver Injury", THE AMERICAN JOURNAL OF PATHOLOGY, vol. 181, no. 3, September 2012 (2012-09-01), pages 804 - 817, XP055109392, ISSN: 0002-9440, DOI: 10.1016/j.ajpath.2012.06.010
VUPPALANCHI RAJ ET AL: "REGULATION OF HEPATIC CYTOCHROME P450 3A (CYP3A) ACTIVITY BY MICRORNAS (MIRNAS)", HEPATOLOGY; 62ND ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-THE-STUDY-OF-LIVER-DISEASES (AASLD), WILEY, USA; SAN FRANCISCO, CA, USA, vol. 54, no. Suppl. 1, October 2011 (2011-10-01), pages 718A, XP008168418, ISSN: 0270-9139, [retrieved on 20110930]
Y.-Z. PAN ET AL: "MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targeting", DRUG METABOLISM AND DISPOSITION, vol. 37, no. 10, 6 July 2009 (2009-07-06), pages 2112 - 2117, XP055051773, ISSN: 0090-9556, DOI: 10.1124/dmd.109.027680
S. BAI ET AL: "MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 46, 2 September 2009 (2009-09-02), pages 32015 - 32027, XP055109621, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.016774
SEONGHO RYU ET AL: "Discovery of Novel Human Breast Cancer MicroRNAs from Deep Sequencing Data by Analysis of Pri-MicroRNA Secondary Structures", PLOS ONE, vol. 6, no. 2, 8 February 2011 (2011-02-08), pages e16403 - e16403, XP055090398, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0016403
ANASTASIS OULAS ET AL: "Finding Cancer-Associated miRNAs: Methods and Tools", MOLECULAR BIOTECHNOLOGY ; PART B OF APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, HUMANA PRESS INC, NEW YORK, vol. 49, no. 1, 24 May 2011 (2011-05-24), pages 97 - 107, XP019931163, ISSN: 1559-0305, DOI: 10.1007/S12033-011-9416-4
N. D. MENDES ET AL: "Current tools for the identification of miRNA genes and their targets", NUCLEIC ACIDS RESEARCH, vol. 37, no. 8, 18 March 2009 (2009-03-18), pages 2419 - 2433, XP055109376, ISSN: 0305-1048, DOI: 10.1093/nar/gkp145
YU QIAO ET AL: "MiR-483-5p controls angiogenesis in vitro and targets serum response factor", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 585, no. 19, 1 September 2011 (2011-09-01), pages 3095 - 3100, XP028300059, ISSN: 0014-5793, [retrieved on 20110901], DOI: 10.1016/J.FEBSLET.2011.08.039
FANYIN MENG ET AL: "Epigenetic Regulation of miR-34a Expression in Alcoholic Liver Injury", THE AMERICAN JOURNAL OF PATHOLOGY, vol. 181, no. 3, September 2012 (2012-09-01), pages 804 - 817, XP055109392, ISSN: 0002-9440, DOI: 10.1016/j.ajpath.2012.06.010
VUPPALANCHI RAJ ET AL: "REGULATION OF HEPATIC CYTOCHROME P450 3A (CYP3A) ACTIVITY BY MICRORNAS (MIRNAS)", HEPATOLOGY; 62ND ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-THE-STUDY-OF-LIVER-DISEASES (AASLD), WILEY, USA; SAN FRANCISCO, CA, USA, vol. 54, no. Suppl. 1, October 2011 (2011-10-01), pages 718A, XP008168418, ISSN: 0270-9139, [retrieved on 20110930]
Y.-Z. PAN ET AL: "MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targeting", DRUG METABOLISM AND DISPOSITION, vol. 37, no. 10, 6 July 2009 (2009-07-06), pages 2112 - 2117, XP055051773, ISSN: 0090-9556, DOI: 10.1124/dmd.109.027680
S. BAI ET AL: "MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 46, 2 September 2009 (2009-09-02), pages 32015 - 32027, XP055109621, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.016774
SEONGHO RYU ET AL: "Discovery of Novel Human Breast Cancer MicroRNAs from Deep Sequencing Data by Analysis of Pri-MicroRNA Secondary Structures", PLOS ONE, vol. 6, no. 2, 8 February 2011 (2011-02-08), pages e16403 - e16403, XP055090398, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0016403
ANASTASIS OULAS ET AL: "Finding Cancer-Associated miRNAs: Methods and Tools", MOLECULAR BIOTECHNOLOGY ; PART B OF APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, HUMANA PRESS INC, NEW YORK, vol. 49, no. 1, 24 May 2011 (2011-05-24), pages 97 - 107, XP019931163, ISSN: 1559-0305, DOI: 10.1007/S12033-011-9416-4
N. D. MENDES ET AL: "Current tools for the identification of miRNA genes and their targets", NUCLEIC ACIDS RESEARCH, vol. 37, no. 8, 18 March 2009 (2009-03-18), pages 2419 - 2433, XP055109376, ISSN: 0305-1048, DOI: 10.1093/nar/gkp145
YU QIAO ET AL: "MiR-483-5p controls angiogenesis in vitro and targets serum response factor", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 585, no. 19, 1 September 2011 (2011-09-01), pages 3095 - 3100, XP028300059, ISSN: 0014-5793, [retrieved on 20110901], DOI: 10.1016/J.FEBSLET.2011.08.039
Attorney, Agent or Firm:
PAVAO, Matthew et al. (P.C.One Financial Cente, Boston MA, US)
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