Title:
MICROSATELLITE INSTABILITY SEQUENCING DATA ANALYSIS METHOD, APPARATUS AND COMPUTER-READABLE MEDIUM
Document Type and Number:
WIPO Patent Application WO/2019/047577
Kind Code:
A1
Abstract:
Provided are a microsatellite instability sequencing data analysis method, an apparatus and a computer-readable medium. The present invention can use an NGS sequencing result to determine whether microsatellite instability is present; the present analysis calculation method significantly increases detection sensitivity without decreasing specificity, and can evaluate stability or instability of each MSI site rapidly, automatically, with high throughput, high flexibility and high specificity, thereby combining states of all MSI sites in each sample, and evaluating a sample overall as MSS, MSI-L or MSI-H.
Inventors:
SHAO YANG (CN)
ZHU MINGFU (CN)
CHANG ZHILI (CN)
WANG XIAONAN (CN)
YAN CHONGGUANG (CN)
WU SHUYU (CN)
BAO HUA (CN)
TONG XIAOLING (CN)
ZHU MINGFU (CN)
CHANG ZHILI (CN)
WANG XIAONAN (CN)
YAN CHONGGUANG (CN)
WU SHUYU (CN)
BAO HUA (CN)
TONG XIAOLING (CN)
Application Number:
PCT/CN2018/090085
Publication Date:
March 14, 2019
Filing Date:
June 06, 2018
Export Citation:
Assignee:
GENESEEQ TECH INC (CN)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2016139534A2 | 2016-09-09 |
Foreign References:
| CN107526944A | 2017-12-29 | |||
| CN106755501A | 2017-05-31 |
Other References:
SALIPANTE, S. J. ET AL.: "Microsatellite Instability Detection by Next Generation Sequencing", CLINICAL CHEMISTRY, vol. 60, no. 9, 31 December 2014 (2014-12-31), pages 1192 - 1199, XP055571285, DOI: doi:10.1373/clinchem.2014.223677
GAN, CHUN ET AL.: "Applicability of Next Generation Sequencing Technology in Microsatellite Instability Testing", GENES, vol. 6, 12 February 2015 (2015-02-12), pages 46 - 59, XP055571289, DOI: doi:10.3390/genes6010046
LIU, GUANGCHEN: "Some Statistical Computation Models and Its Application in Biomedical Information Processing", MEDICINE & PUBLIC HEALTH, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 15 September 2016 (2016-09-15), pages E080 - 1
GAN, CHUN ET AL.: "Applicability of Next Generation Sequencing Technology in Microsatellite Instability Testing", GENES, vol. 6, 12 February 2015 (2015-02-12), pages 46 - 59, XP055571289, DOI: doi:10.3390/genes6010046
LIU, GUANGCHEN: "Some Statistical Computation Models and Its Application in Biomedical Information Processing", MEDICINE & PUBLIC HEALTH, CHINA DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 15 September 2016 (2016-09-15), pages E080 - 1
Attorney, Agent or Firm:
NANJING HUIHENG INTELLECTUAL PROPERTY AGENCY OFFICE (GENERAL PARTNERSHIP) (CN)
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