MICROSPHERES WITH IMPROVED BIOAVAILABILITY CONTAINING POORLY WATER-SOLUBLE DRUGS, AND METHOD FOR PREPARING SAME

Title:

MICROSPHERES WITH IMPROVED BIOAVAILABILITY CONTAINING POORLY WATER-SOLUBLE DRUGS, AND METHOD FOR PREPARING SAME

Document Type and Number:

WIPO Patent Application WO/2010/137888

Kind Code:

A2

Abstract:

Provided are microspheres with improved bioavailability containing poorly water-soluble drugs, oral preparations comprising same, and a method for preparing same. The microspheres containing poorly water-soluble drugs are solid dispersions in which poorly water-soluble drugs are dispersed into non-crystalline forms in a water-soluble macromolecular carrier by a spray drying method, and have the advantages of improving the bioavailability of poorly water-soluble drugs.

Inventors:

KIM KYUNG-HEE (KR)
LEE HYUN-KI (KR)
HWANG JUN-SEOK (KR)
HWANG SU-JONG (KR)
PAI CHAUL-MIN (KR)

Application Number:

PCT/KR2010/003366

Publication Date:

December 02, 2010

Filing Date:

May 27, 2010

Export Citation:

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Assignee:

SAMYANG CORP (KR)
KIM KYUNG-HEE (KR)
LEE HYUN-KI (KR)
HWANG JUN-SEOK (KR)
HWANG SU-JONG (KR)
PAI CHAUL-MIN (KR)

International Classes:

A61K9/16; A61K31/522; A61K47/34; A61K47/38

Domestic Patent References:

WO2001041765A1	2001-06-14
WO1999063968A1	1999-12-16

Foreign References:

JPH031288A	1991-01-07
JPH0328404B2	1991-04-19
US4895726A	1990-01-23
US5880148A	1999-03-09
US20030224059A1	2003-12-04

Other References: