Title:
MICROSTRUCTURE FOR PERCUTANEOUS ABSORPTION, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2017/116076
Kind Code:
A1
Abstract:
The present invention relates to a microstructure including a biocompatible polymer or adhesive, and to a method for preparing the same. The present inventors achieved optimal tip angle and diameter ranges for skin permeation by optimizing height-to-width ratios for each microstructures by shape. In particular, when attached to the skin, B type and C type microstructures of the present invention can increase the penetration rate (60% or higher) of structures and the rate of absorption into the skin of active components by minimizing penetration resistance that is due to skin elasticity. Moreover, D type microstructures of the present invention maximize the mechanical strength of structures by utilizing a triple structure, and thus easily permeate the skin. In the present invention, when a hexagonal arrangement technique is applied to a plurality of microstructures, there is an advantage in that uniform pressure may be transferred to the microstructures as a whole when attached to the skin.
Inventors:
KWON SOON CHANG (KR)
PARK SANG JIN (KR)
KIM JAE SOO (KR)
PARK SANG JIN (KR)
KIM JAE SOO (KR)
Application Number:
PCT/KR2016/015137
Publication Date:
July 06, 2017
Filing Date:
December 22, 2016
Export Citation:
Assignee:
ENDO DERMA CO LTD (KR)
International Classes:
A61M37/00; B29C39/02; B81C1/00; C08L101/16; C09J201/00
Foreign References:
| KR20150100807A | 2015-09-02 | |||
| KR20150037826A | 2015-04-08 | |||
| KR20150041870A | 2015-04-20 | |||
| KR20140141360A | 2014-12-10 | |||
| KR20140094471A | 2014-07-30 | |||
| US6334856B1 | 2002-01-01 | |||
| KR100793615B1 | 2008-01-10 |
Other References:
"Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery", JOURNAL OF CONTROLLED RELEASE, vol. 104, 2005, pages 51 - 66
See also references of EP 3398645A4
See also references of EP 3398645A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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