MICROSTRUCTURE FOR TRANSCUTANEOUS AND INTRACUTANEOUS DRUG DELIVERY OF CYCLOSPORIN A (CSA)

WIPO Patent Application WO/2019/198923

A1

The present invention discloses a microstructure comprising cyclosporin A. A microstructure comprising cyclosporin A according to an embodiment of the present invention comprises: a microstructure; and a coating layer formed by applying a medicinal cyclosporin A fluid containing cyclosporin A to the surface of the microstructure, wherein the medicinal cyclosporine A fluid acts to treat or prevent at least one disease among autoimmune diseases, inflammatory diseases, and transplant rejection after transdermal or intradermal drug delivery thereof.

PARK JUNG HWAN (KR)
CHOI YU JI (KR)
KIM JEE WON (KR)
KIM SANG NYUN (KR)
CHANG JAE JIN (KR)
KIM BO JUN (KR)

PCT/KR2019/001591

October 17, 2019

February 08, 2019

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UNIV GACHON IND ACAD COOP FOUND (KR)
ORIENTBIO INC (KR)

A61K9/00; A61K9/08; A61K9/107; A61K9/127; A61K38/13; A61P29/00; A61P37/00; A61P37/06

JP2018510170A	2018-04-12
KR20170141463A	2017-12-26
KR20080007580A	2008-01-22
KR100894130B1	2009-04-20

LAI, J. ET AL.: "Pharmacokinetics and enhanced oral bioavailability in beagle dogs of cyclosporine A encapsulated in glyceryl monooleate/poloxamer 407 cubic nanoparticles", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 5, 16 December 2010 (2010-12-16), pages 13 - 23, XP55641702
JEONG, H.-R. ET AL.: "Local dermal delivery of cyclosporin A, a hydrophobic and high molecular weight drug, using dissolving microneedles", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 127, 9 February 2018 (2018-02-09), pages 237 - 243, XP55641724

KIM, Youn Gwon (KR)

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