MINI-ADENOVIRAL VECTOR AND METHODS OF USING SAME

Title:

MINI-ADENOVIRAL VECTOR AND METHODS OF USING SAME

Document Type and Number:

WIPO Patent Application WO2002088319

Kind Code:

A3

Abstract:

The present invention provides a method for treating a disorder such as hemophilia. A method of treating in a mammal by administering recombinant virus virions comprising a nucleotide sequence having an adenoviral inverted terminal repeat fusion sequence, packaging signal, a transcriptional control region, and a nucleic acid encoding a therapeutic protein such as FVIII. In addition, the DNA molecule does not encode an adenoviral protein. It is preferred that the virions be adminstered to the mammal under conditions that result in the expression of the therapeutic protein at a level that provides a therapeutic effect in said mammal. In addition, the virions are administered with immunosuppressive agents.

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Inventors:

FANG XIANGMING (US)
HARIHARAN MANGALA J (US)

Application Number:

PCT/US2002/013661

Publication Date:

March 06, 2003

Filing Date:

May 01, 2002

Export Citation:

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Assignee:

GENSTAR THERAPEUTICS CORP (US)
FANG XIANGMING (US)
HARIHARAN MANGALA J (US)

International Classes:

A61K39/395; C07K14/755; C12N5/10; C12N15/12; C12N15/861; A61K48/00; (IPC1-7): A16K48/00; C12N15/12; C12N15/86; C12N15/864; A16K31/4745; A16K39/395

Foreign References:

US20020019361A1	2002-02-14
US6174527B1	2001-01-16
US20020006403A1	2002-01-17

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