Title:
MIRNA INHIBITORS FOR PREVENTING AND TREATING ANEURYSMS, HYPERTENSION, ARDS AND OTHER DISEASES ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION
Document Type and Number:
WIPO Patent Application WO/2022/236161
Kind Code:
A3
Abstract:
The present disclosure relates to pharmaceutical compositions comprising a miRNA inhibitor, as well as the method for using such pharmaceutical compositions.
Inventors:
CAI HUA (US)
Application Number:
PCT/US2022/028296
Publication Date:
August 03, 2023
Filing Date:
May 09, 2022
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
A61K48/00; A61K31/7088; A61P9/00; A61P39/06
Domestic Patent References:
| WO2010120508A2 | 2010-10-21 |
Foreign References:
| US20200384034A1 | 2020-12-10 | |||
| US20150232837A1 | 2015-08-20 |
Other References:
NAKAO TETSUSHI, HORIE TAKAHIRO, BABA OSAMU, NISHIGA MASATAKA, NISHINO TOMOHIRO, IZUHARA MASAYASU, KUWABARA YASUHIDE, NISHI HITOO, : "Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 37, no. 11, 1 November 2017 (2017-11-01), pages 2161 - 2170, XP093080548, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.117.309768
MARQUART TYLER J., WU JUDY, LUSIS ALDONS J., BALDÁN ÁNGEL: "Anti-miR-33 Therapy Does Not Alter the Progression of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 33, no. 3, 1 March 2013 (2013-03-01), pages 455 - 458, XP093080549, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.112.300639
LU CAN, ZHOU DANTING, WANG QIANG, LIU WENLIANG, YU FENGLEI, WU FANG, CHEN CHEN: "Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer", OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, HINDAWI PUBLISHING CORPORATION, US, vol. 2020, 28 April 2020 (2020-04-28), US , pages 1 - 13, XP093080551, ISSN: 1942-0900, DOI: 10.1155/2020/2415324
AIT-AISSA KARIMA, NGUYEN QUYNH MY, GABANI MOHANAD, KASSAN ADAM, KUMAR SANTOSH, CHOI SOO-KYOUNG, GONZALEZ ALEXIS A., KHATAEI TAHSIN: "MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy", CARDIOVASCULAR DIABETOLOGY, vol. 19, no. 1, 1 December 2020 (2020-12-01), pages 136, XP093080555, DOI: 10.1186/s12933-020-01107-3
HUANG KAI, NARUMI TARO, ZHANG YIXUAN, LI QIANG, MURUGESAN PRIYA, WU YUSI, LIU NORIKA MENGCHIA, CAI HUA: "Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation", HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 78, no. 2, 1 August 2021 (2021-08-01), US , pages 282 - 293, XP093080559, ISSN: 0194-911X, DOI: 10.1161/HYPERTENSIONAHA.120.15070
MARQUART TYLER J., WU JUDY, LUSIS ALDONS J., BALDÁN ÁNGEL: "Anti-miR-33 Therapy Does Not Alter the Progression of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 33, no. 3, 1 March 2013 (2013-03-01), pages 455 - 458, XP093080549, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.112.300639
LU CAN, ZHOU DANTING, WANG QIANG, LIU WENLIANG, YU FENGLEI, WU FANG, CHEN CHEN: "Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer", OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, HINDAWI PUBLISHING CORPORATION, US, vol. 2020, 28 April 2020 (2020-04-28), US , pages 1 - 13, XP093080551, ISSN: 1942-0900, DOI: 10.1155/2020/2415324
AIT-AISSA KARIMA, NGUYEN QUYNH MY, GABANI MOHANAD, KASSAN ADAM, KUMAR SANTOSH, CHOI SOO-KYOUNG, GONZALEZ ALEXIS A., KHATAEI TAHSIN: "MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy", CARDIOVASCULAR DIABETOLOGY, vol. 19, no. 1, 1 December 2020 (2020-12-01), pages 136, XP093080555, DOI: 10.1186/s12933-020-01107-3
HUANG KAI, NARUMI TARO, ZHANG YIXUAN, LI QIANG, MURUGESAN PRIYA, WU YUSI, LIU NORIKA MENGCHIA, CAI HUA: "Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation", HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 78, no. 2, 1 August 2021 (2021-08-01), US , pages 282 - 293, XP093080559, ISSN: 0194-911X, DOI: 10.1161/HYPERTENSIONAHA.120.15070
Attorney, Agent or Firm:
HALSTEAD, David P. et al. (US)
Download PDF: