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Title:
MIRNA MARKER FOR DIAGNOSING OSTEOSARCOMA
Document Type and Number:
WIPO Patent Application WO/2017/118230
Kind Code:
A1
Abstract:
Disclosed is a use of miR-4714, miR-4521 and miR-1292 as osteosarcoma diagnosis markers. High-throughput sequencing and QPCR experiments have proven that there are significant differences in the contents of miR-4714, miR-4521 and miR-1292 in the blood of a normal person and in that of an osteosarcoma patient. Therefore, miR-4714, miR-4521 and miR-1292 can be used as the molecular markers for diagnosing osteosarcomas to develop a product for diagnosing osteosarcomas, wherein the diagnosis product has the following advantages: being non-invasive, rapid and sensitive, and having a wide clinical application prospect.

Inventors:
YANG, Zuozhang (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
ZHANG, Ya (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
YANG, Yihao (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
LI, Xiaojuan (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
LI, Dongqi (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
XIA, Junfeng (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
LI, Su (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
ZHANG, Zhaoxin (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
LI, Huiling (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
CHEN, Yanjin (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
Application Number:
CN2016/106567
Publication Date:
July 13, 2017
Filing Date:
November 21, 2016
Export Citation:
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Assignee:
YANG, Zuozhang (Department of Orthopedics, Tumor hospital of YunnanProvince No.519 Kunzhou Roa, Kunming Yunnan 8, 650118, CN)
International Classes:
C12Q1/68; G01N33/574
Domestic Patent References:
WO2014044827A12014-03-27
Foreign References:
CN105561341A2016-05-11
CN105441565A2016-03-30
CN103476947A2013-12-25
US20140206852A12014-07-24
US20130012405A12013-01-10
CN104372007A2015-02-25
CN102421916A2012-04-18
Other References:
WANG, X. F.: "Serum MicroRNA-4521 is a Potential Biomarker for Focal Cortical Dysplasia with Refractory Epilepsy", NEUROCHEM. RES., vol. 41, 8 December 2015 (2015-12-08), XP035925888, DOI: doi:10.1007/s11064-015-1773-0
SAMPSON, VALERIE B.: "MicroRNAs and Potential Targets in Osteosarcoma: Review", FRONTIERS IN PEDIATRICS, vol. 3, 24 August 2015 (2015-08-24), XP055599275, ISSN: 2296-2360, DOI: 10.3389/fped.2015.00069
CAMPS, CARME: "Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia", MOLECULAR CANCER, vol. 13, no. 1, 11 February 2014 (2014-02-11) - 31 December 2014 (2014-12-31), pages 28, XP021176934, ISSN: 1476-4598, DOI: 10.1186/1476-4598-13-28
MIAO, JINGLEI ET AL.: "MicroRNAs in osteosarcoma: diagnostic and therapeutic aspects", TUMOR BIOL., vol. 34, no. 4, 25 June 2013 (2013-06-25) - August 2013 (2013-08-01), pages 2093 - 2098, XP055599283
Attorney, Agent or Firm:
GENUINEWAYS INC. (F3Hong Yun Business Building, No.32 Dongsikuaiyu South Street, Dongcheng District, Beijing 1, 100061, CN)
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