Title:
MIRNA MARKER AND KIT ASSOCIATED WITH POSTMENOPAUSAL OSTEOPOROSIS
Document Type and Number:
WIPO Patent Application WO/2019/033468
Kind Code:
A1
Abstract:
Provided in the present invention is the use of the miR-338 clusters as markers for postmenopausal osteoporosis. The present invention finds that miR-338 clusters such as miR-338-3p and/or miR-3065-5p are highly expressed in patients with postmenopausal osteoporosis, and same can be used as markers for postmenopausal osteoporosis when preparing an auxiliary diagnostic kit for postmenopausal osteoporosis, can specifically detect the expression level of the miR-338 clusters in tissues, and is used for early auxiliary diagnosis of clinic postmenopausal osteoporosis, and is non-invasive. In addition, inhibitors of the miR-338 clusters have the efficacy of promoting osteogenesis and can be used for treating or preventing postmenopausal osteoporosis.
Inventors:
LIU HUAN (CN)
LIN CHUJIAO (CN)
CHEN ZHI (CN)
LIN CHUJIAO (CN)
CHEN ZHI (CN)
Application Number:
PCT/CN2017/100135
Publication Date:
February 21, 2019
Filing Date:
September 01, 2017
Export Citation:
Assignee:
UNIV WUHAN (CN)
International Classes:
A61K45/00; C12Q1/68; A61P19/10
Foreign References:
| CN102573856A | 2012-07-11 |
Other References:
SUN, QIN: "Study on the dual function of miR-338-3p in mouse Odontoblast-Osteoblast differentiation", MEDICINE & PUBLIC HEALTH, 31 January 2016 (2016-01-31)
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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