Title:
MITOCHONDRIAL DNA DAMAGE AS A PREDICTOR OF CORONARY ATHEROSCLEROTIC HEART DISEASE
Document Type and Number:
WIPO Patent Application WO2000041610
Kind Code:
A3
Abstract:
The present invention demonstrates that mitochondrial DNA damage occurs prior to, or simultaneous with, atherosclerotic lesion development, that aortic mitochondrial DNA damage increases with age, and that genotype and diet both influence the level of mitochondrial DNA damage. Hence, the present invention demonstrates that mitochondrial DNA damage occurs early in atherosclerosis, and may be an initiating event in atherogenesis, and provides methods to predict coronary atherosclerotic heart disease based upon the amount of mitochondrial DNA damage.
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Inventors:
RUNGE MARSCHALL S (US)
BALLINGER SCOTT W (US)
VAN HOUTEN BENNETT (US)
BALLINGER SCOTT W (US)
VAN HOUTEN BENNETT (US)
Application Number:
PCT/US2000/001048
Publication Date:
September 28, 2000
Filing Date:
January 14, 2000
Export Citation:
Assignee:
RES DEV FOUNDATION (US)
RUNGE MARSCHALL S (US)
BALLINGER SCOTT W (US)
HOUTEN BENNETT VAN (US)
RUNGE MARSCHALL S (US)
BALLINGER SCOTT W (US)
HOUTEN BENNETT VAN (US)
International Classes:
C12N15/09; C12Q1/68; G01N33/50; C12Q1/6827; C12Q1/6883; G01N33/15; G01N33/48; (IPC1-7): C07H21/04; C12Q1/68
Other References:
CORRAL-DEBRINSKI ET. AL.: "Associaton of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease", MUTATION RESEARCH, vol. 275, 1992, pages 169 - 180, XP002929418
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