Title:
MITOCHONDRIAL PROTEINS CONSTRUCTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/170896
Kind Code:
A3
Abstract:
Disclosed are novel fusion protein constructs comprising a functional mitochondrial protein, that can enter mitochondria within intact cells. Further disclosed are methods of treating mitochondrial disorders by the disclosed fusion proteins and compositions therefor.
Inventors:
LORBERBOUM-GALSKI HAYA (IL)
GREIF HAGAR (IL)
GREIF HAGAR (IL)
Application Number:
PCT/IL2014/050354
Publication Date:
December 31, 2014
Filing Date:
April 10, 2014
Export Citation:
Assignee:
BIO BLAST PHARMA LTD (IL)
International Classes:
A61K48/00; C07K14/435; C12N1/00
Domestic Patent References:
| WO2009098682A2 | 2009-08-13 |
Other References:
C. A. KOCZOR ET AL: "Mitochondrial DNA Damage Initiates a Cell Cycle Arrest by a Chk2-associated Mechanism in Mammalian Cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 52, 19 October 2009 (2009-10-19), pages 36191 - 36201, XP055127240, ISSN: 0021-9258, DOI: 10.1074/jbc.M109.036020
DEL GAIZO V ET AL: "Targeting proteins to mitochondria using TAT", MOLECULAR GENETICS AND METABOLISM, ACADEMIC PRESS, AMSTERDAM, NL, vol. 80, no. 1-2, 1 September 2003 (2003-09-01), pages 170 - 180, XP002986585, ISSN: 1096-7192, DOI: 10.1016/J.YMGME.2003.08.017
DEL GAIZO V ET AL: "Targeting proteins to mitochondria using TAT", MOLECULAR GENETICS AND METABOLISM, ACADEMIC PRESS, AMSTERDAM, NL, vol. 80, no. 1-2, 1 September 2003 (2003-09-01), pages 170 - 180, XP002986585, ISSN: 1096-7192, DOI: 10.1016/J.YMGME.2003.08.017
Attorney, Agent or Firm:
REINHOLD COHN & PARTNERS (62 Tel-Aviv, IL)
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