Title:
MITOCHONDRIAL RIBOSOMAL PROTEINS AS AGING REGULATORS
Document Type and Number:
WIPO Patent Application WO/2013/024467
Kind Code:
A3
Abstract:
The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods forscreening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject.
Inventors:
AUWERX JOHAN (CH)
HOUTKOOPER RICHARDUS (CH)
MOUCHIROUD LAURENT (CH)
HOUTKOOPER RICHARDUS (CH)
MOUCHIROUD LAURENT (CH)
Application Number:
PCT/IB2012/054206
Publication Date:
July 04, 2013
Filing Date:
August 20, 2012
Export Citation:
Assignee:
ECOLE POLYTECH (CH)
AUWERX JOHAN (CH)
HOUTKOOPER RICHARDUS (CH)
MOUCHIROUD LAURENT (CH)
AUWERX JOHAN (CH)
HOUTKOOPER RICHARDUS (CH)
MOUCHIROUD LAURENT (CH)
International Classes:
A61K31/713; C12N15/11; G01N33/50
Domestic Patent References:
| WO2003087768A2 | 2003-10-23 | |||
| WO2001083524A2 | 2001-11-08 |
Foreign References:
| US20030082120A1 | 2003-05-01 |
Other References:
JOHAN AUWERX: "Protein homeostasis in the control of mitochondrial function and aging", 14 June 2012 (2012-06-14), pages 10, XP002689993, Retrieved from the Internet [retrieved on 20130108]
HOUTKOOPER RIEKELT H ET AL: "The metabolic footprint of aging in mice", SCIENTIFIC REPORTS,, vol. 1, 1 October 2011 (2011-10-01), XP002682477
HARRISON DAVID E ET AL: "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.", NATURE 16 JUL 2009, vol. 460, no. 7253, 16 July 2009 (2009-07-16), pages 392 - 395, XP002689994, ISSN: 1476-4687
MICHIHIKO FUJII ET AL: "Mutation in a mitochondrial ribosomal protein causes increased sensitivity to oxygen with decreased longevity in the nematode Caenorhabditis elegans", GENES TO CELLS, vol. 16, no. 1, 13 December 2010 (2010-12-13), pages 69 - 79, XP055048845, ISSN: 1356-9597, DOI: 10.1111/j.1365-2443.2010.01469.x
LEE SIU SYLVIA ET AL: "A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 33, no. 1, 1 January 2003 (2003-01-01), pages 40 - 48, XP002320682, ISSN: 1061-4036, DOI: 10.1038/NG1056
MOUCHIROUD LAURENT ET AL: "Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.", BIOFACTORS (OXFORD, ENGLAND) 2010 SEP-OCT, vol. 36, no. 5, September 2010 (2010-09-01), pages 377 - 382, XP002689995, ISSN: 1872-8081
RIEKELT H. HOUTKOOPER ET AL: "Metabolic Networks of Longevity", CELL, vol. 142, no. 1, 1 July 2010 (2010-07-01), pages 9 - 14, XP055036518, ISSN: 0092-8674, DOI: 10.1016/j.cell.2010.06.029
HAMILTON BENJAMIN ET AL: "A systematic RNAi screen for longevity genes in C. elegans", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, vol. 19, no. 13, 1 July 2005 (2005-07-01), pages 1544 - 1555, XP009166044, ISSN: 0890-9369
HEEREN GINO ET AL: "The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1", HOW TO TRACK CELLULAR AGING OF MESENCHYMAL STROMAL CELLS?,, vol. 1, no. 7, 1 July 2009 (2009-07-01), pages 622 - 636, XP009165991, ISSN: 1945-4589, [retrieved on 20090713]
SUZUKI T ET AL: "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 31 AUG 2001, vol. 276, no. 35, 31 August 2001 (2001-08-31), pages 33181 - 33195, XP002690059, ISSN: 0021-9258
HOUTKOOPER RIEKELT H ET AL: "The metabolic footprint of aging in mice", SCIENTIFIC REPORTS,, vol. 1, 1 October 2011 (2011-10-01), XP002682477
HARRISON DAVID E ET AL: "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.", NATURE 16 JUL 2009, vol. 460, no. 7253, 16 July 2009 (2009-07-16), pages 392 - 395, XP002689994, ISSN: 1476-4687
MICHIHIKO FUJII ET AL: "Mutation in a mitochondrial ribosomal protein causes increased sensitivity to oxygen with decreased longevity in the nematode Caenorhabditis elegans", GENES TO CELLS, vol. 16, no. 1, 13 December 2010 (2010-12-13), pages 69 - 79, XP055048845, ISSN: 1356-9597, DOI: 10.1111/j.1365-2443.2010.01469.x
LEE SIU SYLVIA ET AL: "A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 33, no. 1, 1 January 2003 (2003-01-01), pages 40 - 48, XP002320682, ISSN: 1061-4036, DOI: 10.1038/NG1056
MOUCHIROUD LAURENT ET AL: "Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.", BIOFACTORS (OXFORD, ENGLAND) 2010 SEP-OCT, vol. 36, no. 5, September 2010 (2010-09-01), pages 377 - 382, XP002689995, ISSN: 1872-8081
RIEKELT H. HOUTKOOPER ET AL: "Metabolic Networks of Longevity", CELL, vol. 142, no. 1, 1 July 2010 (2010-07-01), pages 9 - 14, XP055036518, ISSN: 0092-8674, DOI: 10.1016/j.cell.2010.06.029
HAMILTON BENJAMIN ET AL: "A systematic RNAi screen for longevity genes in C. elegans", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, vol. 19, no. 13, 1 July 2005 (2005-07-01), pages 1544 - 1555, XP009166044, ISSN: 0890-9369
HEEREN GINO ET AL: "The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1", HOW TO TRACK CELLULAR AGING OF MESENCHYMAL STROMAL CELLS?,, vol. 1, no. 7, 1 July 2009 (2009-07-01), pages 622 - 636, XP009165991, ISSN: 1945-4589, [retrieved on 20090713]
SUZUKI T ET AL: "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 31 AUG 2001, vol. 276, no. 35, 31 August 2001 (2001-08-31), pages 33181 - 33195, XP002690059, ISSN: 0021-9258
Attorney, Agent or Firm:
REUTELER & CIE SA (1260 Nyon, CH)
Download PDF:
Previous Patent: SUTURE PASSING INSTRUMENTATION AND METHODS OF USE THEREOF
Next Patent: DEAERATION APPARATUS AND METHOD
Next Patent: DEAERATION APPARATUS AND METHOD