Title:
MITOGEN-ACTIVATED PROTEIN KINASE-DEPENDENT RECOMBINANT VACCINIA VIRUS (MD-RVV) AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/076422
Kind Code:
A1
Abstract:
Provided is a vaccinia virus that specifically grows in cancer cells and destroys the cancer cells. Also provided is utilization of said virus in cancer treatment. A mitogen-activated protein kinase-dependent vaccinia virus that lacks a vaccinia virus growth factor (VGF) and O1L function, specifically grows in cancer cells but does not grow in normal cells, and has oncolytic properties for specifically destroying the cancer cells.
Inventors:
NAKAMURA TAKAFUMI (JP)
Application Number:
PCT/JP2014/081484
Publication Date:
May 28, 2015
Filing Date:
November 20, 2014
Export Citation:
Assignee:
NAT UNIV CORP TOTTORI UNIV (JP)
CHEMO SERO THERAPEUT RES INST (JP)
CHEMO SERO THERAPEUT RES INST (JP)
International Classes:
C12N15/09; A61K35/76; A61K39/00; A61K39/002; A61K39/02; A61K39/12; A61K39/275; A61K48/00; A61P31/04; A61P31/12; A61P33/02; A61P35/00; A61P35/02; A61P37/04; C12N7/00
Domestic Patent References:
| WO2012142529A2 | 2012-10-18 | |||
| WO2011125469A1 | 2011-10-13 | |||
| WO2013038066A1 | 2013-03-21 | |||
| WO2005054451A1 | 2005-06-16 |
Foreign References:
| JP2013241299A | 2013-12-05 |
Other References:
ANDRADE, A. A. ET AL.: "The vaccinia virus- stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication", BIOCHEMICAL JOURNAL, vol. 381, 2004, pages 437 - 446, XP055344778
SCHWENEKER, M. ET AL.: "The Vaccinia Virus 01 Protein Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase 1/2 and Promotes Viral Virulence", JOURNAL OF VIROLOGY, vol. 86, no. 4, 14 December 2011 (2011-12-14), pages 2323 - 2336, XP055344779
MCCART, J. A. ET AL.: "Systemic Cancer Therapy with a Tumor-selective Vaccinia Virus Mutant Lacking Thymidine Kinase and Vaccinia Growth Factor Genes", CANCER RESEARCH, vol. 61, 2001, pages 8751 - 8757, XP008121980
TAKASHI NAKAMURA ET AL.: "Oncolytic virotherapy", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 67, no. 956, 2009, pages 572 - 576, XP008183315
SCHWENEKER M. ET AL., JOURNAL OF VIROLOGY, vol. 86, no. 4, 2012, pages 2323 - 2336
BULLER RM. ET AL., JOURNAL OF VIROLOGY, vol. 62, no. 3, 1988, pages 866 - 874
MCCART JA. ET AL., CANCER RESEARCH, vol. 61, no. 24, 2001, pages 8751 - 8757
SO HASHIZUME, CLINICAL VIROLOGY, vol. 3, no. 3, 1975, pages 269
PROTEIN, NUCLEIC ACID, ENZYME, vol. 48, no. 12, 2003, pages 1693 - 1700
"Transgene & Expression Analysis Experiment Method", 1 September 1997, YODOSHA
TAKARA ET AL.: "EMBO Journal", vol. 6, 1987, article "DNA Cloning 4: Mammalian Systems", pages: 3379 - 3384
HAMMOND JM. ET AL., JOURNAL OF VIROLOGICAL METHODS, vol. 66, no. 1, 1997, pages 135 - 138
SUZUKI H. ET AL., VACCINE, vol. 27, no. 7, 2009, pages 966 - 971
SCHWENEKER, M. ET AL.: "The Vaccinia Virus 01 Protein Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase 1/2 and Promotes Viral Virulence", JOURNAL OF VIROLOGY, vol. 86, no. 4, 14 December 2011 (2011-12-14), pages 2323 - 2336, XP055344779
MCCART, J. A. ET AL.: "Systemic Cancer Therapy with a Tumor-selective Vaccinia Virus Mutant Lacking Thymidine Kinase and Vaccinia Growth Factor Genes", CANCER RESEARCH, vol. 61, 2001, pages 8751 - 8757, XP008121980
TAKASHI NAKAMURA ET AL.: "Oncolytic virotherapy", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 67, no. 956, 2009, pages 572 - 576, XP008183315
SCHWENEKER M. ET AL., JOURNAL OF VIROLOGY, vol. 86, no. 4, 2012, pages 2323 - 2336
BULLER RM. ET AL., JOURNAL OF VIROLOGY, vol. 62, no. 3, 1988, pages 866 - 874
MCCART JA. ET AL., CANCER RESEARCH, vol. 61, no. 24, 2001, pages 8751 - 8757
SO HASHIZUME, CLINICAL VIROLOGY, vol. 3, no. 3, 1975, pages 269
PROTEIN, NUCLEIC ACID, ENZYME, vol. 48, no. 12, 2003, pages 1693 - 1700
"Transgene & Expression Analysis Experiment Method", 1 September 1997, YODOSHA
TAKARA ET AL.: "EMBO Journal", vol. 6, 1987, article "DNA Cloning 4: Mammalian Systems", pages: 3379 - 3384
HAMMOND JM. ET AL., JOURNAL OF VIROLOGICAL METHODS, vol. 66, no. 1, 1997, pages 135 - 138
SUZUKI H. ET AL., VACCINE, vol. 27, no. 7, 2009, pages 966 - 971
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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