Title:
MITOTIC KINESIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO2003050122
Kind Code:
A3
Abstract:
The present invention relates to furanopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
Inventors:
FRALEY MARK E (US)
HARTMAN GEORGE D (US)
HARTMAN GEORGE D (US)
Application Number:
PCT/US2002/038487
Publication Date:
December 04, 2003
Filing Date:
December 02, 2002
Export Citation:
Assignee:
MERCK & CO INC (US)
FRALEY MARK E (US)
HARTMAN GEORGE D (US)
FRALEY MARK E (US)
HARTMAN GEORGE D (US)
International Classes:
A61K31/138; A61K31/4465; A61K31/4535; A61K31/519; A61K31/5377; A61K31/541; A61K31/551; A61K31/5517; A61K39/395; A61K45/00; A61P35/00; C07D491/04; C07D491/048; C07D519/00; (IPC1-7): C07D491/048; C07D413/12; C07D413/14; A61K31/519; A61P35/00
Other References:
VAIDYA V.P. ET AL.: "Studies in benzofurans. Part XII. Synthesis and reactions of 2-chloromethyl-3,4-dihydro-4-oxobenzofuro(3,2-d)pyrimidine", INDIAN JOURNAL OF CHEMISTRY. SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 20B, no. 9, 1981, pages 780 - 783, XP002944144
DEBONIS S. ET AL.: "Interaction of the mitotic inhibitor monastrol with human kinesin Eg5", BIOCHEMISTRY, vol. 42, no. 2, January 2003 (2003-01-01), pages 338 - 349, XP002964262
DEBONIS S. ET AL.: "Interaction of the mitotic inhibitor monastrol with human kinesin Eg5", BIOCHEMISTRY, vol. 42, no. 2, January 2003 (2003-01-01), pages 338 - 349, XP002964262
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