Title:
MIXTURE OF ORGANIC ACID AND AMINO GROUP-CONTAINING COMPOUND FORMING AMORPHOUS STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2021/187472
Kind Code:
A1
Abstract:
The present invention provides a means that can mask the odd taste of dipeptide sweeteners and the bitterness of amino acids, that increases the dissolution rate of amino acids, that involves less time and effort during production, that has less restrictions regarding the compositional makeup and use application, and that does not use expensive peptides. This mixture is characterized in that an amorphous structure is formed by an organic acid and an amino group-containing compound, and is particularly characterized in that the amino group-containing compound is a peptide or an amino acid.
Inventors:
SEN JUN (JP)
Application Number:
PCT/JP2021/010576
Publication Date:
September 23, 2021
Filing Date:
March 16, 2021
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
A23L5/00; A23L2/00; A23L27/00; A23L27/21; A61K47/12; A61K47/18
Domestic Patent References:
| WO2018113891A1 | 2018-06-28 |
Other References:
UEDA HIROSHI, WU WENQI, LÖBMANN KORBINIAN, GROHGANZ HOLGER, MÜLLERTZ ANETTE, RADES THOMAS: "Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazapine, Citric Acid, and L-Arginine", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 5, 9 April 2018 (2018-04-09), US , pages 2036 - 2044, XP055859132, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.8b00174
KASTEN, G ET AL.: "Development of a screening method for co-amorphous formulations of drugs and amino acids", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 95, 2016, pages 28 - 35, XP055859136
WU WENQI, UEDA HIROSHI, LÖBMANN KORBINIAN, RADES THOMAS, GROHGANZ HOLGER: "Organic acids as co-formers for co-amorphous systems – Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM., NL, vol. 131, 1 October 2018 (2018-10-01), NL , pages 25 - 32, XP055859138, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2018.07.016
JENSEN KATRINE TARP, BLAABJERG LASSE INGERSLEV, LENZ ELISABETH, BOHR ADAM, GROHGANZ HOLGER, KLEINEBUDDE PETER, RADES THOMAS, LÖBMA: "Preparation and characterization of spray-dried co-amorphous drug–amino acid salts", JOURNAL OF PHARMACY AND PHARMACOLOGY : JPP, JOHN WILEY & SONS LTD, LONDON, GB, vol. 68, no. 5, 25 May 2016 (2016-05-25), GB , pages 615 - 624, XP055859140, ISSN: 0022-3573, DOI: 10.1111/jphp.12458
MISHRA JAYA, RADES THOMAS, LÖBMANN KORBINIAN, GROHGANZ HOLGER: "Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations", PHARMACEUTICS, vol. 10, no. 47, 12 April 2018 (2018-04-12), pages 1 - 13, XP055859143, DOI: 10.3390/pharmaceutics10020047
KASTEN, G ET AL.: "Development of a screening method for co-amorphous formulations of drugs and amino acids", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 95, 2016, pages 28 - 35, XP055859136
WU WENQI, UEDA HIROSHI, LÖBMANN KORBINIAN, RADES THOMAS, GROHGANZ HOLGER: "Organic acids as co-formers for co-amorphous systems – Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM., NL, vol. 131, 1 October 2018 (2018-10-01), NL , pages 25 - 32, XP055859138, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2018.07.016
JENSEN KATRINE TARP, BLAABJERG LASSE INGERSLEV, LENZ ELISABETH, BOHR ADAM, GROHGANZ HOLGER, KLEINEBUDDE PETER, RADES THOMAS, LÖBMA: "Preparation and characterization of spray-dried co-amorphous drug–amino acid salts", JOURNAL OF PHARMACY AND PHARMACOLOGY : JPP, JOHN WILEY & SONS LTD, LONDON, GB, vol. 68, no. 5, 25 May 2016 (2016-05-25), GB , pages 615 - 624, XP055859140, ISSN: 0022-3573, DOI: 10.1111/jphp.12458
MISHRA JAYA, RADES THOMAS, LÖBMANN KORBINIAN, GROHGANZ HOLGER: "Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations", PHARMACEUTICS, vol. 10, no. 47, 12 April 2018 (2018-04-12), pages 1 - 13, XP055859143, DOI: 10.3390/pharmaceutics10020047
Attorney, Agent or Firm:
TANAKA Masahiro (JP)
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